Escitalopram oxalate inhibits proliferation and migration and induces apoptosis in non-small cell lung cancer cells

Yuan,I; Horng,Chi‑Ting; Chen,Vincent  Chin‑Hung; Chen,Chun‑Hung; Chen,Li‑Jeng; Hsu,Tsai‑Ching; Tzang,Bor‑Show

doi:10.3892/ol.2017.7687

Escitalopram oxalate inhibits proliferation and migration and induces apoptosis in non-small cell lung cancer cells

Authors:
- I Yuan
- Chi‑Ting Horng
- Vincent Chin‑Hung Chen
- Chun‑Hung Chen
- Li‑Jeng Chen
- Tsai‑Ching Hsu
- Bor‑Show Tzang
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Affiliations: Department of Pharmacy, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C., Department of Ophthalmology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, R.O.C., Department of Psychiatry, Chang Gung University, Taoyuan 33302, Taiwan, R.O.C., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C.
Published online on: December 21, 2017 https://doi.org/10.3892/ol.2017.7687
Pages: 3376-3382

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Abstract

Population-based cohort studies have revealed that neuroleptic medications are associated with a reduced cancer risk. Recent studies have demonstrated that selective serotonin reuptake inhibitors (SSRIs) have an antiproliferative or cytotoxic effect on certain cancer types. Known as a superior SSRI, escitalopram oxalate exhibits favorable tolerability with generally mild and temporary adverse events. The present study aimed to examine the effects of escitalopram oxalate on non‑small cell lung cancer (NSCLC) cells. The experimental results revealed that escitalopram oxalate significantly inhibited the proliferation and invasion of A549, and H460 cells compared with BEAS‑2B cells. Additionally, escitalopram oxalate significantly increased the sub‑G1 population and caspase‑3 activity of A549, and H460 cells. Furthermore, escitalopram oxalate significantly induced mitochondria‑dependent apoptotic signaling cascades in A549 and H460 cells, which included increases in the protein expression levels of apoptosis regulator Bax, truncated BH3‑interacting domain death agonist, cytochrome c, apoptotic protease‑activating factor 1, and cleaved caspase‑9. These findings suggest that escitalopram oxalate could serve a therapeutic agent for the treatment of NSCLC due to its antiproliferative and apoptotic effects.

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