Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.

  • Authors:
    • Xiu‑Mei Li
    • Xue‑Gang Luo
    • Jun‑Fang He
    • Nan Wang
    • Hao Zhou
    • Pei‑Long Yang
    • Tong‑Cun Zhang
  • View Affiliations

  • Published online on: January 16, 2018     https://doi.org/10.3892/ol.2018.7812
  • Pages: 3944-3950
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Abstract

Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer activity compounds from H. ascyron L. and the underlying molecular mechanism. Anticancer activity of H. ascyron L. extract was evaluated using an MTT assay. To confirm the anticancer mechanism of activity compounds, Hoechst 33258, Annexin V‑fluorescein isothiocyanate/propidium iodide, 2',7'‑dichlorodihydrofluorescein diacetate, rhodamine 123 staining and caspase‑3 activity analysis were performed. The results demonstrated that the anti‑proliferative action of the mixture of kaempferol 3‑O‑β‑(2
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li XM, Luo XG, He JF, Wang N, Zhou H, Yang PL and Zhang TC: Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.. Oncol Lett 15: 3944-3950, 2018
APA
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., & Zhang, T. (2018). Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.. Oncology Letters, 15, 3944-3950. https://doi.org/10.3892/ol.2018.7812
MLA
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., Zhang, T."Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.". Oncology Letters 15.3 (2018): 3944-3950.
Chicago
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., Zhang, T."Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.". Oncology Letters 15, no. 3 (2018): 3944-3950. https://doi.org/10.3892/ol.2018.7812