Specific organ metastases and survival in small cell lung cancer

Nakazawa,Kensuke; Kurishima,Koichi; Tamura,Tomohiro; Kagohashi,Katsunori; Ishikawa,Hiroichi; Satoh,Hiroaki; Hizawa,Nobuyuki

doi:10.3892/ol.2012.792

October 2012 Volume 4 Issue 4

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October 2012 Volume 4 Issue 4

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Article

Specific organ metastases and survival in small cell lung cancer

Authors:
- Kensuke Nakazawa
- Koichi Kurishima
- Tomohiro Tamura
- Katsunori Kagohashi
- Hiroichi Ishikawa
- Hiroaki Satoh
- Nobuyuki Hizawa
View Affiliations / Copyright

Affiliations: Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Mito, Ibaraki 305‑8575, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki 305-8558, Japan
Pages: 617-620
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Published online on: July 9, 2012

https://doi.org/10.3892/ol.2012.792
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Abstract

The aim of our retrospective study was to evaluate the clinicopathological features associated with distant metastasis from small cell lung cancer (SCLC). We reviewed patients diagnosed with SCLC metastasis at the time of presentation between 1999 and 2010. Among the consecutive 251 SCLC patients diagnosed, 152 (60.6%) patients had distant metastasis, of which 20.3, 18.3, 15.5, 10.0 and 6.0% of patients had liver, bone, brain, lung and adrenal gland metastasis, respectively. In a multivariate analysis using Cox's proportional hazards model, we identified that liver, bone and brain metastasis as well as the presence of pleural and/or pericardial fluids were unfavorable prognostic factors. However, lung, adrenal gland and extrathoracic lymph node metastasis were not statistically significant prognostic factors. With regard to the treatment of SCLC patients, particularly those with liver, bone and brain metastasis or pleural and/or pericardial fluids, we should take the metastasizing organs into consideration.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Specific organ metastases and survival in small cell lung cancer

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Abstract

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