Specific organ metastases and survival in small cell lung cancer
- Authors:
- Kensuke Nakazawa
- Koichi Kurishima
- Tomohiro Tamura
- Katsunori Kagohashi
- Hiroichi Ishikawa
- Hiroaki Satoh
- Nobuyuki Hizawa
View Affiliations
Affiliations: Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Mito, Ibaraki 305‑8575, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki 305-8558, Japan
- Published online on: July 9, 2012 https://doi.org/10.3892/ol.2012.792
-
Pages:
617-620
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Abstract
The aim of our retrospective study was to evaluate the clinicopathological features associated with distant metastasis from small cell lung cancer (SCLC). We reviewed patients diagnosed with SCLC metastasis at the time of presentation between 1999 and 2010. Among the consecutive 251 SCLC patients diagnosed, 152 (60.6%) patients had distant metastasis, of which 20.3, 18.3, 15.5, 10.0 and 6.0% of patients had liver, bone, brain, lung and adrenal gland metastasis, respectively. In a multivariate analysis using Cox's proportional hazards model, we identified that liver, bone and brain metastasis as well as the presence of pleural and/or pericardial fluids were unfavorable prognostic factors. However, lung, adrenal gland and extrathoracic lymph node metastasis were not statistically significant prognostic factors. With regard to the treatment of SCLC patients, particularly those with liver, bone and brain metastasis or pleural and/or pericardial fluids, we should take the metastasizing organs into consideration.
View References
1.
|
R FerraldeschiS BakaB JyotiC Faivre-FinnN
ThatcherP LoriganModern management of small-cell lung
cancerDrugs6721352152200710.2165/00003495-200767150-0000317927281
|
2.
|
NR FosterSJ MandrekarSE SchildPrognostic
factors differ by tumor stage for small cell lung cancer: a pooled
analysis of North Central Cancer Treatment Group
trialsCancer11527212731200910.1002/cncr.2431419402175
|
3.
|
W TravisE BrambillaH Muller-HermelinkC
HarrisTumours of the lung, pleura, thymus and heartPathology and
Genetics World Health Organisation Classification of TumoursIARC
PressLyon2004
|
4.
|
M ZelenKeynote address on biostatistics
and data retrievalCancer Chemother Rep 34314219734580860
|
5.
|
FA ShepherdRJ GinsbergR HaddadImportance
of clinical staging in limited small-cell lung cancer: a valuable
system to separate prognostic subgroups. The University of Toronto
Lung Oncology GroupJ Clin Oncol111592159719938393098
|
6.
|
DR CoxRegression models and life tablesJ
Roy Statist Soc Ser B Metho341872201972
|
7.
|
WR BezwodaD LewisN LiviniBone marrow
involvement in anaplastic small cell lung cancer. Diagnosis,
hematologic features, and prognostic
implicationsCancer5817621765198610.1002/1097-0142(19861015)58:8%3C1762::AID-CNCR2820580830%3E3.0.CO;2-V3019512
|
8.
|
J ZychZ PolowiecE WiatrA BroniekE
Rowinska-ZakrzewskaThe prognostic significance of bone marrow
metastases in small cell lung cancer patientsLung
Cancer10239245199310.1016/0169-5002(93)90184-Y8075969
|
9.
|
F TasA AydinerE TopuzH CamlicaP SaipY
EralpFactors influencing the distribution of metastases and
survival in extensive disease small cell lung cancerActa
Oncol3810111015199910.1080/02841869943227510665754
|
10.
|
J LiCH DaiP ChenSurvival and prognostic
factors in small cell lung cancerMed
Oncol277381201010.1007/s12032-009-9174-319214813
|
11.
|
M TamuraH UeokaK KiuraPrognostic factors
of small-cell lung cancer in Okayama Lung Cancer Study Group
TrialsActa Med Okayama5210511119989588226
|
12.
|
RM BremnesS SundstromU AasebøS KaasaR
HatlevollS AamdalNorweigian Lung Cancer Study GroupThe value of
prognostic factors in small cell lung cancer: results from a
randomised multicenter study with minimum 5 year follow-upLung
Cancer39303313200312609569
|
13.
|
A MohanA GoyalP SinghSurvival in small
cell lung cancer in India: prognostic utility of clinical features,
laboratory parameters and response to treatmentIndian J
Cancer436774200610.4103/0019-509X.2588716790943
|
14.
|
S ArincU GonlugurO DevranPrognostic
factors in patients with small cell lung carcinomaMed
Oncol27237241201010.1007/s12032-009-9198-819399653
|
15.
|
ES NussbaumHR DjalilianKH ChoWA HallBrain
metastases. Histology, multiplicity, surgery, and
survivalCancer7817811988199610.1002/(SICI)1097-0142(19961015)78:8%3C1781::AID-CNCR19%3E3.0.CO;2-U8859192
|
16.
|
K KagohashiH SatohH IshikawaM OhtsukaK
SekizawaLiver metastasis at the time of initial diagnosis of lung
cancerMed Oncol202528200310.1385/MO:20:1:2512665681
|
17.
|
M ObaraH SatohYT YamashitaMetastatic small
cell lung cancer causing biliary obstructionMed
Oncol15292294199810.1007/BF027872179951697
|
18.
|
R OgawaT KodamaK KurishimaK KagohashiH
SatohPortal vein tumor thrombus of liver metastasis from lung
cancerActa Medica (Hradec Kralove)52163166200920369711
|
19.
|
SH Ignatius OuJA ZellThe applicability of
the proposed IASLC staging revisions to small cell lung cancer
(SCLC) with comparison to the current UICC 6th TNM EditionJ Thorac
Oncol4300310200919156001
|
20.
|
FA ShepherdJ CrowleyP Van HoutteThe
International Association for the Study of Lung Cancer lung cancer
staging project: proposals regarding the clinical staging of small
cell lung cancer in the forthcoming (seventh) edition of the tumor,
node, metastasis classification for lung cancerJ Thorac
Oncol210671077200710.1097/JTO.0b013e31815bdc0d
|