Vascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma

  • Authors:
    • Yasue Kimura
    • Masayuki Watanabe
    • Takefumi Ohga
    • Hiroshi Saeki
    • Yoshihiro Kakeji
    • Hideo Baba
    • Yoshihiko Maehara
  • View Affiliations

  • Published online on: November 1, 2003     https://doi.org/10.3892/or.10.6.1747
  • Pages: 1747-1751
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Abstract

Vascular endothelial growth factor C (VEGF-C), a member of VEGF gene family, is considered to induce both lymph node metastasis and lymphatic involvement in various cancers related to lymphangiogenesis. We examined the relationship between VEGF-C expression and clinicopathological features in 112 Japanese patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy and reconstruction without preoperative treatment. VEGF-C expression was examined using immunohistochemical staining and RT-PCR in surgically resected tissues. Regarding VEGF-C there were positive findings in 44 (39.3%) cases. VEGF-C expression in ESCC significantly correlated with the depth of tumor (p=0.0131), lymph node metastasis (p=0.0211), lymphatic involvement (p<0.0001) and pathological stage (p=0.0164). The prognosis for the VEGF-C positive group was poorer than that for the VEGF-C negative group (p=0.038). Multivariate analysis indicated that VEGF-C expression in ESCC is an independent factor only in cases of lymphatic involvement. VEGF-C expression in ESCC may play a great key role in lymphatic spread and this may be a consideration in terms of deciding the most appropriate treatment.

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November-December 2003
Volume 10 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kimura Y, Watanabe M, Ohga T, Saeki H, Kakeji Y, Baba H and Maehara Y: Vascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma. Oncol Rep 10: 1747-1751, 2003.
APA
Kimura, Y., Watanabe, M., Ohga, T., Saeki, H., Kakeji, Y., Baba, H., & Maehara, Y. (2003). Vascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma. Oncology Reports, 10, 1747-1751. https://doi.org/10.3892/or.10.6.1747
MLA
Kimura, Y., Watanabe, M., Ohga, T., Saeki, H., Kakeji, Y., Baba, H., Maehara, Y."Vascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma". Oncology Reports 10.6 (2003): 1747-1751.
Chicago
Kimura, Y., Watanabe, M., Ohga, T., Saeki, H., Kakeji, Y., Baba, H., Maehara, Y."Vascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma". Oncology Reports 10, no. 6 (2003): 1747-1751. https://doi.org/10.3892/or.10.6.1747