search button

Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line

  • Authors:
    • Hitoshi Yamazaki
    • Akiyoshi Handa
    • Masatake Nishi
    • Tetsuji Tokunaga
    • Masashi Tomisawa
    • Hiroyuki Hatanaka
    • Yoshiyuki Abe
    • Hiroshi Kijima
    • Yoshito Ueyama
    • Masato Nakamura

  • View Affiliations

  • Published online on: February 1, 2004     https://doi.org/10.3892/or.11.2.371
  • Pages: 371-374
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Thrombospondin-1 (TSP1) is known to possess tumor suppressor functions. In contradiction, TSP1 enhances the stromal vascularization and growth of certain cancers. A cell adhesion receptor, CD36, has been shown to interact with a ligand TSP1. We studied how CD36 affects the growth of the osteosarcoma cell line (HOS) expressing TSP1. We used the anti-CD36 ribozyme to specifically suppress CD36 gene expression in the HOS. The expression of the CD36 mRNA was significantly suppressed in the ribozyme-introduced cell line (HOS/Rz). The transformant HOS/Rz markedly decreased its growth. The growth of the osteosarcoma cell line HOS may be regulated by autocrine or paracrine loop TSP1 and CD36.

Related Articles

Journal Cover

February 2004
Volume 11 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Yamazaki H, Handa A, Nishi M, Tokunaga T, Tomisawa M, Hatanaka H, Abe Y, Kijima H, Ueyama Y, Nakamura M, Nakamura M, et al: Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. Oncol Rep 11: 371-374, 2004.
APA
Yamazaki, H., Handa, A., Nishi, M., Tokunaga, T., Tomisawa, M., Hatanaka, H. ... Nakamura, M. (2004). Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. Oncology Reports, 11, 371-374. https://doi.org/10.3892/or.11.2.371
MLA
Yamazaki, H., Handa, A., Nishi, M., Tokunaga, T., Tomisawa, M., Hatanaka, H., Abe, Y., Kijima, H., Ueyama, Y., Nakamura, M."Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line". Oncology Reports 11.2 (2004): 371-374.
Chicago
Yamazaki, H., Handa, A., Nishi, M., Tokunaga, T., Tomisawa, M., Hatanaka, H., Abe, Y., Kijima, H., Ueyama, Y., Nakamura, M."Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line". Oncology Reports 11, no. 2 (2004): 371-374. https://doi.org/10.3892/or.11.2.371