Combination celecoxib and temozolomide in C6 rat glioma orthotopic model

  • Authors:
    • Seok-Gu Kang
    • Jong Soo Kim
    • Kwan Park
    • Morris D. Groves
    • Do-Hyun Nam
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/or.15.1.7
  • Pages: 7-13
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Abstract

The purpose of this study was to determine whether a combination treatment of temozolomide with celecoxib is effective in the rat orthotopic glioma model. After stereotactic injection of C6/LacZ rat glioma cells into the Sprague Dawley rat brain, the rats were randomly assigned to four treatment groups [group 1, control treatment; group 2, celecoxib (25 mg/kg p.o. everyday) alone; group 3, temozolomide (7.5 mg/kg i.p. for 5 days at 2nd week) alone; group 4, a combination of celecoxib and temozolomide]. Rats were sacrificed 18 days after treatment, and the body weight, tumor volume, tumor cell proliferation, microvessel densities, and apoptosis were evaluated. There was a significant reduction of tumor volume in combination group compared to control or single-agent therapy. The median tumor volume was estimated to be 111.5 mm3 (control), 65.0 mm3 (celecoxib), 71.8 mm3 (temozolomide) and 18.7 mm3 (combination). In the combination group, there was increased tumor cell apoptosis as well as decreased microvessel density and tumor cell proliferation relative to the control and single-agent therapy (P<0.05). Collectively, the data suggest that the combination celecoxib and temozolomide may provide a novel and effective approach to the treatment of glioblastoma.

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January 2006
Volume 15 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kang S, Kim JS, Park K, Groves MD and Nam D: Combination celecoxib and temozolomide in C6 rat glioma orthotopic model. Oncol Rep 15: 7-13, 2006.
APA
Kang, S., Kim, J.S., Park, K., Groves, M.D., & Nam, D. (2006). Combination celecoxib and temozolomide in C6 rat glioma orthotopic model. Oncology Reports, 15, 7-13. https://doi.org/10.3892/or.15.1.7
MLA
Kang, S., Kim, J. S., Park, K., Groves, M. D., Nam, D."Combination celecoxib and temozolomide in C6 rat glioma orthotopic model". Oncology Reports 15.1 (2006): 7-13.
Chicago
Kang, S., Kim, J. S., Park, K., Groves, M. D., Nam, D."Combination celecoxib and temozolomide in C6 rat glioma orthotopic model". Oncology Reports 15, no. 1 (2006): 7-13. https://doi.org/10.3892/or.15.1.7