Expression profile of class I histone deacetylases in human cancer tissues

  • Authors:
    • Masamune Nakagawa
    • Yoshinao Oda
    • Takashi Eguchi
    • Shin-Ichi Aishima
    • Takashi Yao
    • Fumihito Hosoi
    • Yuji Basaki
    • Mayumi Ono
    • Michihiko Kuwano
    • Masao Tanaka
    • Masazumi Tsuneyoshi
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/or.18.4.769
  • Pages: 769-774
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Abstract

Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.

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October 2007
Volume 18 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nakagawa M, Oda Y, Eguchi T, Aishima S, Yao T, Hosoi F, Basaki Y, Ono M, Kuwano M, Tanaka M, Tanaka M, et al: Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep 18: 769-774, 2007.
APA
Nakagawa, M., Oda, Y., Eguchi, T., Aishima, S., Yao, T., Hosoi, F. ... Tsuneyoshi, M. (2007). Expression profile of class I histone deacetylases in human cancer tissues. Oncology Reports, 18, 769-774. https://doi.org/10.3892/or.18.4.769
MLA
Nakagawa, M., Oda, Y., Eguchi, T., Aishima, S., Yao, T., Hosoi, F., Basaki, Y., Ono, M., Kuwano, M., Tanaka, M., Tsuneyoshi, M."Expression profile of class I histone deacetylases in human cancer tissues". Oncology Reports 18.4 (2007): 769-774.
Chicago
Nakagawa, M., Oda, Y., Eguchi, T., Aishima, S., Yao, T., Hosoi, F., Basaki, Y., Ono, M., Kuwano, M., Tanaka, M., Tsuneyoshi, M."Expression profile of class I histone deacetylases in human cancer tissues". Oncology Reports 18, no. 4 (2007): 769-774. https://doi.org/10.3892/or.18.4.769