Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy

  • Authors:
    • Bishnuhari Paudyal
    • Noboru Oriuchi
    • Pramila Paudyal
    • Yoshito Tsushima
    • Yasuhiko Iida
    • Tetsuya Higuchi
    • Hirofumi Hanaoka
    • Mitsuyuki Miyakubo
    • Akie Takano
    • Tomohiro Ishikita
    • Keigo Endo
  • View Affiliations

  • Published online on: December 1, 2007     https://doi.org/10.3892/or.18.6.1469
  • Pages: 1469-1473
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Abstract

The aim of this study was to evaluate the role of positron emission tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (18F-FDG) in the restaging of hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA). This study was performed on 33 lesions in 24 patients with HCC. 18F-FDG PET and computed tomography (CT) studies were performed in all patients before treatment. PET acquisition was started 50-60 min after injection of 18F-FDG (5-6 MBq/kg). Semi-quantitative analysis using Standardized Uptake Value (SUV) was measured for the evaluation of tumour 18F-FDG uptake. All patients underwent RFA treatment and were followed up at least 2 years with 18F-FDG PET, CT and clinical evaluation in the interval of every 3 months in the first year and every 6 months in the second year. 18F-FDG PET detected recurrence earlier than CT between 4-6 months in 2 patients and between 7-9 months in 6 patients whereas CT was positive in 4 patients. Overall detection rate of recurrence with 18F-FDG PET was 92% which was higher than that of CT (75%). Statistically significant difference in the SUV was observed between well and moderately differentiated HCC (p=0.033) and also between well and poorly differentiated HCC (p=0.037). The size of tumours showed a significant correlation with the time of recurrence (p<0.00033, r=0.8601, n=12). The results of this study indicate that 18F-FDG PET could detect recurrence earlier in patients with HCC treated with RFA, as compared with CT and could diagnose extrahepatic lesions. SUV showed a significant correlation with time of recurrence after RFA. 18F-FDG PET may be a dominant imaging modality as a follow-up procedure of HCC after RFA, in terms of early detection of recurrence.

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December 2007
Volume 18 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Paudyal B, Oriuchi N, Paudyal P, Tsushima Y, Iida Y, Higuchi T, Hanaoka H, Miyakubo M, Takano A, Ishikita T, Ishikita T, et al: Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy. Oncol Rep 18: 1469-1473, 2007.
APA
Paudyal, B., Oriuchi, N., Paudyal, P., Tsushima, Y., Iida, Y., Higuchi, T. ... Endo, K. (2007). Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy. Oncology Reports, 18, 1469-1473. https://doi.org/10.3892/or.18.6.1469
MLA
Paudyal, B., Oriuchi, N., Paudyal, P., Tsushima, Y., Iida, Y., Higuchi, T., Hanaoka, H., Miyakubo, M., Takano, A., Ishikita, T., Endo, K."Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy". Oncology Reports 18.6 (2007): 1469-1473.
Chicago
Paudyal, B., Oriuchi, N., Paudyal, P., Tsushima, Y., Iida, Y., Higuchi, T., Hanaoka, H., Miyakubo, M., Takano, A., Ishikita, T., Endo, K."Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy". Oncology Reports 18, no. 6 (2007): 1469-1473. https://doi.org/10.3892/or.18.6.1469