Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas

  • Authors:
    • Sung P. Hong
    • Eun K. Lee
    • Jeong Y. Park
    • Tae J. Jeon
    • Seungmin Bang
    • Seungwoo Park
    • Jae B. Chung
    • Woo J. Lee
    • Hoguen Kim
    • Si Y. Song
  • View Affiliations

  • Published online on: January 1, 2009     https://doi.org/10.3892/or_00000184
  • Pages: 19-24
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Abstract

Human Cripto-1, a membrane-bound protein, plays an important role during early embryogenesis and has oncogenic properties, including cell transformation and enhancement of invasion. Cripto-1 is up-regulated in various malignant tissues and premalignant lesions. However, Cripto-1 expression in intraductal papillary mucinous neoplasms (IPMNs) has yet to be reported. This study aimed to investigate Cripto-1 expression in IPMNs and evaluate the expression patterns according to the histological grade or phenotypic subclassification. Cripto-1 expression was evaluated by immunohistochemistry using 37 IPMN tissue samples and real-time RT-PCR analysis of seven frozen samples. Cripto-1 was up-regulated in 59.5% of IPMNs. Cripto-1 was positively stained in 3 of 4 (75%) adenomas, 12 of 19 (63.2%) borderline neoplasms, 5 of 11 (45.5%) non-invasive carcinomas and 2 of 3 (66.7%) invasive carcinomas. There was no correlation between Cripto-1 overexpression and the histological grade (P>0.05). Cripto-1 expression was significantly increased in pancreatobiliary- (4/5, 80%) and gastric-type (13/19, 68.4.2%) IPMNs compared with those of the intestinal type (2/10, 20%; P<0.01). Cripto-1 mRNA expression was higher in gastric- and pancreatobiliary-type IPMNs than in intestinal ones, supporting the immunohistochemical results. It is concluded that Cripto-1 overexpression is involved in the tumorigenesis of gastric- and pancreatobiliary-type IPMNs.

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January 2009
Volume 21 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hong SP, Lee EK, Park JY, Jeon TJ, Bang S, Park S, Chung JB, Lee WJ, Kim H, Song SY, Song SY, et al: Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas. Oncol Rep 21: 19-24, 2009.
APA
Hong, S.P., Lee, E.K., Park, J.Y., Jeon, T.J., Bang, S., Park, S. ... Song, S.Y. (2009). Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas. Oncology Reports, 21, 19-24. https://doi.org/10.3892/or_00000184
MLA
Hong, S. P., Lee, E. K., Park, J. Y., Jeon, T. J., Bang, S., Park, S., Chung, J. B., Lee, W. J., Kim, H., Song, S. Y."Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas". Oncology Reports 21.1 (2009): 19-24.
Chicago
Hong, S. P., Lee, E. K., Park, J. Y., Jeon, T. J., Bang, S., Park, S., Chung, J. B., Lee, W. J., Kim, H., Song, S. Y."Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas". Oncology Reports 21, no. 1 (2009): 19-24. https://doi.org/10.3892/or_00000184