Epstein-Barr virus detection in invasive and pre-invasive lesions of the uterine cervix

  • Authors:
    • Nelly Beatriz Modós Santos
    • Fabiola Elizabeth Villanova
    • Priscila Maria Andrade
    • Julisa Ribalta
    • José Focchi
    • Audrey Yumi Otsuka
    • Ismael Dale Silva
  • View Affiliations

  • Published online on: February 1, 2009     https://doi.org/10.3892/or_00000236
  • Pages: 403-405
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Abstract

In the present study, our aim was to investigate whether EBV DNA could be found in association with invasive and pre-invasive cervical cancer lesions. We hypothesize that EBV is not merely a commensal agent when present in malignant cervical lesions. DNA was extracted from cervical scrapings followed by nested PCR-based amplification. The patients were 66 women with high grade cervical intraepithelial neoplasia and 14 women with invasive cervical cancer. The control group consisted of 89 women with a normal Pap smear and colposcopy as well as a negative HPV DNA test. Analysis of our results, in conjunction with the work of other authors, leads us to propose that EBV is not merely a commensal agent when present in malignant cervical lesions. The presence of DNA from EBV is significantly associated with cervical cancer.

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February 2009
Volume 21 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Santos NB, Villanova FE, Andrade PM, Ribalta J, Focchi J, Otsuka AY and Dale Silva I: Epstein-Barr virus detection in invasive and pre-invasive lesions of the uterine cervix. Oncol Rep 21: 403-405, 2009.
APA
Santos, N.B., Villanova, F.E., Andrade, P.M., Ribalta, J., Focchi, J., Otsuka, A.Y., & Dale Silva, I. (2009). Epstein-Barr virus detection in invasive and pre-invasive lesions of the uterine cervix. Oncology Reports, 21, 403-405. https://doi.org/10.3892/or_00000236
MLA
Santos, N. B., Villanova, F. E., Andrade, P. M., Ribalta, J., Focchi, J., Otsuka, A. Y., Dale Silva, I."Epstein-Barr virus detection in invasive and pre-invasive lesions of the uterine cervix". Oncology Reports 21.2 (2009): 403-405.
Chicago
Santos, N. B., Villanova, F. E., Andrade, P. M., Ribalta, J., Focchi, J., Otsuka, A. Y., Dale Silva, I."Epstein-Barr virus detection in invasive and pre-invasive lesions of the uterine cervix". Oncology Reports 21, no. 2 (2009): 403-405. https://doi.org/10.3892/or_00000236