HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin

  • Authors:
    • Qinqin Zuo
    • Wenjing Wu
    • Xu Li
    • Le Zhao
    • Wei Chen
  • View Affiliations

  • Published online on: November 15, 2011     https://doi.org/10.3892/or.2011.1553
  • Pages: 819-824
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Abstract

Histone deacetylase 6 (HDAC6) promotes cell motility and contributes to the metastasis of cancers. The purpose of this study was to investigate the role of HDAC6 in human bladder cancer for the first time. The results showed that HDAC6 promotes the migration and invasion of bladder cancer cells by targeting the cytoskeletal protein cortactin. Furthermore, a colony formation assay as well as in vitro migration and invasion assays demonstrated that this migration and invasion was suppressed by the HDAC6-specific inhibitor tubacin. In addition, cortactin is the substrate of SIRT2, which also belongs to the family of histone deacetylases. We demonstrated that by using SIRT2-specific siRNA combined with tubacin treatment, the cell migratory and invasive abilities were dramatically suppressed. Taken together, we conclude that HDAC6 and SIRT2 work synergistically to promote cell migration and invasion in bladder cancer, and the HDAC6-specific inhibitor tubacin may be regarded as a novel therapeutic agent for bladder cancer.

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March 2012
Volume 27 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zuo Q, Wu W, Li X, Zhao L and Chen W: HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncol Rep 27: 819-824, 2012.
APA
Zuo, Q., Wu, W., Li, X., Zhao, L., & Chen, W. (2012). HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncology Reports, 27, 819-824. https://doi.org/10.3892/or.2011.1553
MLA
Zuo, Q., Wu, W., Li, X., Zhao, L., Chen, W."HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin". Oncology Reports 27.3 (2012): 819-824.
Chicago
Zuo, Q., Wu, W., Li, X., Zhao, L., Chen, W."HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin". Oncology Reports 27, no. 3 (2012): 819-824. https://doi.org/10.3892/or.2011.1553