Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells

  • Authors:
    • Guodong Wang
    • Liming Song
    • Huiping Wang
    • Nianzeng Xing
  • View Affiliations

  • Published online on: May 15, 2013     https://doi.org/10.3892/or.2013.2469
  • Pages: 357-363
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Abstract

Lack of effective treatment options for castration-resistant prostate cancer reinforces the great need to develop novel drug therapies. Quercetin is a plant-derived flavonoid that can induce apoptosis in prostate cancer cells. 2-Methoxyestradiol (2-ME) is an endogenous estrogenic metabolite that also has antineoplastic activity. However, these two agents have limited bioavailability. Herein, we explored the antiproliferative and proapoptotic activities of quercetin combined with 2-ME in both androgen-dependent LNCaP and androgen-independent PC-3 human prostate cancer cell lines. Compared to quercetin and 2-ME alone, combining quercetin with 2-ME at appropriate concentrations i) showed synergistic antiproliferative and proapoptotic activities; ii) increased G2/M phase population of cells; iii) decreased the ratio of Bcl-2/Bax significantly. The combination of quercetin and 2-ME is a new clinically relevant treatment regimen which has the potential of enhancing the antitumor effect on prostate cancer and lessening the side effect of either quercetin or 2-ME alone.

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July 2013
Volume 30 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wang G, Song L, Wang H and Xing N: Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Oncol Rep 30: 357-363, 2013.
APA
Wang, G., Song, L., Wang, H., & Xing, N. (2013). Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Oncology Reports, 30, 357-363. https://doi.org/10.3892/or.2013.2469
MLA
Wang, G., Song, L., Wang, H., Xing, N."Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells". Oncology Reports 30.1 (2013): 357-363.
Chicago
Wang, G., Song, L., Wang, H., Xing, N."Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells". Oncology Reports 30, no. 1 (2013): 357-363. https://doi.org/10.3892/or.2013.2469