Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7

  • Authors:
    • Huaqi Yin
    • Zhengzuo Sheng
    • Xiaowei Zhang
    • Yiqing Du
    • Caipeng Qin
    • Huixin Liu
    • Yaojun Dun
    • Qi Wang
    • Chengyue Jin
    • Yanhui Zhao
    • Tao Xu
  • View Affiliations

  • Published online on: December 2, 2016     https://doi.org/10.3892/or.2016.5288
  • Pages: 1045-1051
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Abstract

Sex determining region Y (SRY)-box 18 (SOX18) gene encodes transcription factors that have been recently confirmed to be overexpressed in various human types of cancer and maintain the malignant behavior of cancer cells. However, the role and its potential function in prostate cancer (PCa) has not been demonstrated and the mechanisms of SOX18 involved in tumor progression remain largely unclear. In the present study, the expression of SOX18 was analyzed in 98 PCa and 81 adjacent non-tumor tissues using immunohistochemistry. The data showed that SOX18 was overexpressed in 72 of 98 (73.5%) PCa tissues compared with that in 28 of 81 (34.6%) non-tumor tissues. In addition, the expression of SOX18 was related with the clinical features of patients with PCa. To explore the potential role of SOX18 in PCa cells, Cell Counting Kit-8 (CCK-8), migration, invasion and xenograft assays were performed. Our data showed that knockdown of SOX18 decreased the proliferation, migration and invasion of PCa cells in vitro, in addition to the tumor growth in vivo. Markedly, SOX18 knockdown caused the decreased expression of TCF1, c-Myc, cyclin D1 and MMP-7. In conclusion, SOX18 was overexpressed in PCa and may regulate the malignant capacity of cells via the upregulation of TCF1, c-Myc, cyclin D1 and MMP-7.
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February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yin H, Sheng Z, Zhang X, Du Y, Qin C, Liu H, Dun Y, Wang Q, Jin C, Zhao Y, Zhao Y, et al: Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7. Oncol Rep 37: 1045-1051, 2017
APA
Yin, H., Sheng, Z., Zhang, X., Du, Y., Qin, C., Liu, H. ... Xu, T. (2017). Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7. Oncology Reports, 37, 1045-1051. https://doi.org/10.3892/or.2016.5288
MLA
Yin, H., Sheng, Z., Zhang, X., Du, Y., Qin, C., Liu, H., Dun, Y., Wang, Q., Jin, C., Zhao, Y., Xu, T."Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7". Oncology Reports 37.2 (2017): 1045-1051.
Chicago
Yin, H., Sheng, Z., Zhang, X., Du, Y., Qin, C., Liu, H., Dun, Y., Wang, Q., Jin, C., Zhao, Y., Xu, T."Overexpression of SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7". Oncology Reports 37, no. 2 (2017): 1045-1051. https://doi.org/10.3892/or.2016.5288