Open Access

Suppression of YAP by DDP disrupts colon tumor progression

Retraction in: /10.3892/or.2020.7843

  • Authors:
    • Kun Li
    • Jiwei Guo
    • Yan Wu
    • Dan Jin
    • Hong Jiang
    • Chengxia Liu
    • Chengyong Qin
  • View Affiliations

  • Published online on: March 6, 2018     https://doi.org/10.3892/or.2018.6297
  • Pages: 2114-2126
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colon cancer is a commonly diagnosed cancer that often has a poor prognosis. Combined with the development of drug resistance to cancer treatment agents the treatment efficacy of colon cancer can be limited. Activation of the oncogene YAP has been shown to be related to colon cancer progression and is associated with poor prognosis, drug resistance and metastasis, even under treatment. Cisplatin (DDP) is a commonly used drug that can control carcinoma progression, although its mechanisms are poorly understood. In the present study, we examined whether DDP specifically suppressed YAP in order to inhibit colon carcinoma progression. Our data revealed that Mst/Yap signaling was unusually activated in colon cancers, promoting cell proliferation and invasion. DDP treatment decreased the expression of YAP at both the transcriptional and post-translational levels, leading to cell cycle arrest, apoptosis and senescence in cancer cells, in addition to decreasing epithelial-to-mesenchymal transition, cell motility and in vitro cell invasion and migration. Ultimately, DDP increased the expression of E-cadherin and decreased the expression of vimentin. The present study also revealed that post-translational regulation of YAP phosphorylation controlled the subcellular distribution between the nucleus and the cytoplasm. In conclusion, the findings of the present study revealed that DDP was a suitable therapeutic candidate for colon cancer that specifically targets the Mst/Yap signaling pathway.
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May-2018
Volume 39 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li K, Guo J, Wu Y, Jin D, Jiang H, Liu C and Qin C: Suppression of YAP by DDP disrupts colon tumor progression Retraction in /10.3892/or.2020.7843. Oncol Rep 39: 2114-2126, 2018
APA
Li, K., Guo, J., Wu, Y., Jin, D., Jiang, H., Liu, C., & Qin, C. (2018). Suppression of YAP by DDP disrupts colon tumor progression Retraction in /10.3892/or.2020.7843. Oncology Reports, 39, 2114-2126. https://doi.org/10.3892/or.2018.6297
MLA
Li, K., Guo, J., Wu, Y., Jin, D., Jiang, H., Liu, C., Qin, C."Suppression of YAP by DDP disrupts colon tumor progression Retraction in /10.3892/or.2020.7843". Oncology Reports 39.5 (2018): 2114-2126.
Chicago
Li, K., Guo, J., Wu, Y., Jin, D., Jiang, H., Liu, C., Qin, C."Suppression of YAP by DDP disrupts colon tumor progression Retraction in /10.3892/or.2020.7843". Oncology Reports 39, no. 5 (2018): 2114-2126. https://doi.org/10.3892/or.2018.6297