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The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man

  • Authors:
    • M ElMofty
    • N AbdelMeguid
    • I Sadek
    • A Essawy
    • E AbdelAleem

  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/or.4.3.657
  • Pages: 657-660
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Injection of Egyptian toads Bufo regularis, with adriamycin subcutaneously in the dorsal lymph sac at a dose level of 0.1 mg/toad, once every 3 weeks for 3 months induced pronounced alterations in the blood cells. These alterations were more or less similar to the criteria reported in human leukaemia. These changes were all comparable to those observed after the treatment of the experimental animals with the chemical carcinogen 7,12-dimethylbenz(a)anthracene. It is speculated that toads (Bufo regularis) can be used as biological test animals for screening chemicals or drugs which induce leukaemia in man.

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May 1997
Volume 4 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
ElMofty M, AbdelMeguid N, Sadek I, Essawy A and AbdelAleem E: The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man. Oncol Rep 4: 657-660, 1997.
APA
ElMofty, M., AbdelMeguid, N., Sadek, I., Essawy, A., & AbdelAleem, E. (1997). The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man. Oncology Reports, 4, 657-660. https://doi.org/10.3892/or.4.3.657
MLA
ElMofty, M., AbdelMeguid, N., Sadek, I., Essawy, A., AbdelAleem, E."The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man". Oncology Reports 4.3 (1997): 657-660.
Chicago
ElMofty, M., AbdelMeguid, N., Sadek, I., Essawy, A., AbdelAleem, E."The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man". Oncology Reports 4, no. 3 (1997): 657-660. https://doi.org/10.3892/or.4.3.657