Current advances in animal model of chondrosarcoma and related research (Review)

Liao,Yu-Xin; Hua,Ying-Qi; Cai,Zheng-Dong

doi:10.3892/br.2012.13

Current advances in animal model of chondrosarcoma and related research (Review)

Authors:
- Yu-Xin Liao
- Ying-Qi Hua
- Zheng-Dong Cai
View Affiliations

Affiliations: Musculoskeletal Oncology Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
Published online on: October 1, 2012 https://doi.org/10.3892/br.2012.13
Pages: 3-6

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Chondrosarcoma is a type of malignant cartilage tumor with a high local recurrence. Due to its resistance to chemo‑ and radiotherapy, current treatment is limited to surgical resection. Animal model is one of the most important approaches to studying this disease, although systematic reporting on its development is rare. In this review, we summarized the elements involving animal model establishment. On the basis of these elements, we further classified chondrosarcoma animal models into various types. In addition, we compared various measurements for evaluating the animal model. Finally, its specific applications were discussed.

View Figures

View References

1.	Clark JC, Akiyama T, Dass CR and Choong PF: New clinically relevant, orthotopic mouse models of human chondrosarcoma with spontaneous metastasis. Cancer Cell Int. 10:202010. View Article : Google Scholar : PubMed/NCBI
2.	Hemmati M, Abbaspour A, Alizadeh AM, et al: Rat xenograft chondrosarcoma development by human tissue fragment. Exp Oncol. 33:52–54. 2011.PubMed/NCBI
3.	Li TM, Lin TY, Hsu SF, et al: The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells. Mol Carcinog. 50:791–803. 2011. View Article : Google Scholar : PubMed/NCBI
4.	Bergh P, Gunterberg B, Meis-Kindblom JM and Kindblom LG: Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: a center-based study of 69 cases. Cancer. 91:1201–1212. 2001. View Article : Google Scholar : PubMed/NCBI
5.	Fiorenza F, Abudu A, Grimer RJ, et al: Risk factors for survival and local control in chondrosarcoma of bone. J Bone Joint Surg Br. 84:93–99. 2002. View Article : Google Scholar : PubMed/NCBI
6.	Bruns J, Elbracht M and Niggemeyer O: Chondrosarcoma of bone: an oncological and functional follow-up study. Ann Oncol. 12:859–864. 2001. View Article : Google Scholar : PubMed/NCBI
7.	Qureshi A, Ahmad Z, Azam M and Idrees R: Epidemiological data for common bone sarcomas. Asian Pac J Cancer Prev. 11:393–395. 2010.PubMed/NCBI
8.	Gelderblom H, Hogendoorn PC, Dijkstra SD, et al: The clinical approach towards chondrosarcoma. Oncologist. 13:320–329. 2008. View Article : Google Scholar : PubMed/NCBI
9.	Ozaki T, Hillmann A, Lindner N, Blasius S and Winkelmann W: Metastasis of chondrosarcoma. J Cancer Res Clin Oncol. 122:625–628. 1996. View Article : Google Scholar
10.	Maibenco HC, Krehbiel RH and Nelson D: Transplantable osteogenic tumor in the rat. Cancer Res. 27:362–366. 1967.PubMed/NCBI
11.	Stevens JW: Heterogeneity in growth properties of the rat Swarm chondrosarcoma. Iowa Orthop J. 24:33–35. 2004.PubMed/NCBI
12.	Mason RM and Bansal MK: Different growth rates of swarm chondrosarcoma in Lewis and Wistar rats correlate with different thyroid hormone levels. Connect Tissue Res. 16:177–185. 1987. View Article : Google Scholar : PubMed/NCBI
13.	Clark JC, Dass CR and Choong PF: Development of chondrosarcoma animal models for assessment of adjuvant therapy. ANZ J Surg. 79:327–336. 2009. View Article : Google Scholar : PubMed/NCBI
14.	Folkman J: The role of angiogenesis in tumor growth. Semin Cancer Biol. 3:65–71. 1992.
15.	Kenan S and Steiner GC: Experimental transplantation of the Swarm rat chondrosarcoma into bone: radiological and pathological studies. J Orthop Res. 9:445–451. 1991. View Article : Google Scholar : PubMed/NCBI
16.	Grimaud E, Damiens C, Rousselle AV, Passuti N, Heymann D and Gouin F: Bone remodelling and tumour grade modifications induced by interactions between bone and swarm rat chondrosarcoma. Histol Histopathol. 17:1103–1111. 2002.PubMed/NCBI
17.	Klenke FM, Abdollahi A, Bertl E, et al: Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo. BMC Cancer. 7:492007. View Article : Google Scholar : PubMed/NCBI
18.	Hamm CA, Stevens JW, Xie H, et al: Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors. BMC Cancer. 10:4712010. View Article : Google Scholar : PubMed/NCBI
19.	Gouin F, Ory B, Redini F and Heymann D: Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival. Int J Cancer. 119:980–984. 2006. View Article : Google Scholar
20.	O’Neill K, Lyons SK, Gallagher WM, Curran KM and Byrne AT: Bioluminescent imaging: a critical tool in pre-clinical oncology research. J Pathol. 220:317–327. 2010.PubMed/NCBI
21.	Jenkins DE, Oei Y, Hornig YS, et al: Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis. Clin Exp Metastasis. 20:733–744. 2003. View Article : Google Scholar : PubMed/NCBI
22.	Comstock KE, Hall CL, Daignault S, Mandlebaum SA, Yu C and Keller ET: A bioluminescent orthotopic mouse model of human osteosarcoma that allows sensitive and rapid evaluation of new therapeutic agents In vivo. In Vivo. 23:661–668. 2009.
23.	Honigman A, Zeira E, Ohana P, et al: Imaging transgene expression in live animals. Mol Ther. 4:239–249. 2001. View Article : Google Scholar : PubMed/NCBI
24.	Sarraf-Yazdi S, Mi J, Dewhirst MW and Clary BM: Use of in vivo bioluminescence imaging to predict hepatic tumor burden in mice. J Surg Res. 120:249–255. 2004. View Article : Google Scholar : PubMed/NCBI
25.	Doyle TC, Burns SM and Contag CH: In vivo bioluminescence imaging for integrated studies of infection. Cell Microbiol. 6:303–317. 2004. View Article : Google Scholar : PubMed/NCBI
26.	Liu R, Wolinsky JB, Catalano PJ, et al: Paclitaxel-eluting polymer film reduces locoregional recurrence and improves survival in a recurrent sarcoma model: a novel investigational therapy. Ann Surg Oncol. 19:199–206. 2012. View Article : Google Scholar : PubMed/NCBI
27.	Yonekawa M, Kondo S, Sugiura H, et al: Serum cartilage-derived retinoic acid-sensitive protein (CD-RAP) levels in swarm rat chondrosarcoma. J Orthop Res. 20:382–386. 2002. View Article : Google Scholar : PubMed/NCBI