Polymorphisms of DNA repair and oxidative stress genes in B-cell lymphoma patients

Fabisiewicz,Anna; Pacholewicz,Katarzyna; Paszkiewicz‑Kozik,Ewa; Walewski,Jan; Siedlecki,Janusz  A.

doi:10.3892/br.2012.31

Polymorphisms of DNA repair and oxidative stress genes in B-cell lymphoma patients

Authors:
- Anna Fabisiewicz
- Katarzyna Pacholewicz
- Ewa Paszkiewicz‑Kozik
- Jan Walewski
- Janusz A. Siedlecki
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Affiliations: Department of Molecular Biology, The Maria Sklodowska‑Curie Memorial Institute and Oncology Centre, PL-02-781 Warsaw, Poland, Department of Lymphoid Malignancies, The Maria Sklodowska‑Curie Memorial Institute and Oncology Centre, PL-02-781 Warsaw, Poland
Published online on: October 25, 2012 https://doi.org/10.3892/br.2012.31
Pages: 151-155

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Abstract

The purpose of the study was to investigate the possible association between ERCC2 rs28365048, ERCC5 rs17655, XRCC3 rs861539 and NOS2A rs2297518 polymorphisms with B‑cell lymphoma. The study was conducted on 189 patients with CD20+ B‑cell lymphoma and 193 controls. The genotype frequencies were compared in the patient and control groups using quantitative polymerase chain reaction, based on allelic discrimination analysis. Our results indicated that variation in NOS2A may be significant in B‑cell lymphoma in a population ≥50 years old (OR=2.15; 95% CI, 1.17‑3.92; P=0.013). No association was observed between variations in ERCC2, ERCC5, XRCC3 and B‑cell lymphoma in the studied population. Our finding of an association between age and NOS2A polymorphisms in lymphoma is unique and requires additional studies. The results concerning ERCC2, ERCC5 and XRCC3 variations add additional data to studies on genetic polymorphisms in the DNA repair pathway.

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