Irregular arrangement of collecting venules (IRAC) provides a critical endoscopic insight in Helicobacter pylori-induced gastritis: A secondary publication

Katake,Yoshiki; Ichikawa,Kazuhito; Fujio,Chikau; Tomita,Shigeki; Imura,Johji; Fujimori,Takahiro

doi:10.3892/br.2012.8

Irregular arrangement of collecting venules (IRAC) provides a critical endoscopic insight in Helicobacter pylori-induced gastritis: A secondary publication

Authors:
- Yoshiki Katake
- Kazuhito Ichikawa
- Chikau Fujio
- Shigeki Tomita
- Johji Imura
- Takahiro Fujimori
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Affiliations: Katake Clinic (Ichouka Naika), Hyogo, Japan, Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Tochigi, Japan, Fujio Clinic, Hyogo, Japan, Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
Published online on: September 3, 2012 https://doi.org/10.3892/br.2012.8
Pages: 23-27

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Abstract

The aim of this study was to evaluate the significance of an endoscopic atrophic border and irregular arrangement of collecting venules (IRAC) in the diagnosis of Helicobacter pylori (H. pylori)‑induced gastritis. Upper gastrointestinal tract endoscopy was performed on 723 patients, who were screened them for H. pylori infection. Any patients who had undergone H. pylori eradication therapy were excluded from the study. The endoscopic atrophic border and IRAC in each patient were assessed. The H. pylori status was determined in the patients by combination of a serological test and/or histopathological examination. The H. pylori infection rates were 95.4% (455/477) in the group with an endoscopic atrophic border and 22.3% (55/246) in the group without an endoscopic atrophic border. In the diagnostic validity check, presence of an endoscopic atrophic border had a sensitivity of 89.2% and a specificity of 89.7%. Furthermore, the H. pylori infection rates were 95.5% (506/530) in the IRAC group and 2.1% (4/193) in the regular arrangement of collecting venules (RAC) group. In the diagnostic validity check, IRAC had a sensitivity of 99.2% and a specificity of 88.7%. In conclusion, the presence of an endoscopic atrophic border and IRAC are highly indicative of an H. pylori‑infected gastric mucosa.

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1.	Marshall B and Warren JR: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1:1311–1315. 1984. View Article : Google Scholar : PubMed/NCBI
2.	NIH consensus conference. Helicobacter pylori in peptic ulcer disease. NIH consensus development panel on Helicobacter pylori in peptic ulcer disease. JAMA. 272:65–69. 1994.
3.	Uemura N, Okamoto S, Yamamoto S, et al: Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 345:784–789. 2001. View Article : Google Scholar
4.	Parsonnet J, Friedman GD, Vandersteen DP, et al: Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 325:1127–1131. 1991. View Article : Google Scholar
5.	Huang JQ, Sridhar S, Chen Y and Hunt RH: Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology. 114:1169–1179. 1998. View Article : Google Scholar : PubMed/NCBI
6.	Blaser MJ and Parsonnet J: Parasitism by the ‘slow’ bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest. 94:4–8. 1994.
7.	Wotherspoon AC, Doglioni C, Diss TC, et al: Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 342:575–577. 1993. View Article : Google Scholar : PubMed/NCBI
8.	Mihara M, Haruma K, Kamada T, et al: The role of endoscopic findings for the diagnosis of Helicobacter pylori infection: evaluation in a country with high prevalence of atrophic gastritis. Helicobacter. 4:40–48. 1999.PubMed/NCBI
9.	Satoh K, Kimura K, Taniguchi Y, et al: Distribution of inflammation and atrophy in the stomach of Helicobacter pylori-positive and -negative patients with chronic gastritis. Am J Gastroenterol. 91:963–969. 1996.PubMed/NCBI
10.	Kawaguchi H, Haruma K, Komoto K, et al: Helicobacter pylori infection is the major risk factor for atrophic gastritis. Am J Gastroenterol. 91:959–962. 1996.
11.	Ishida M, Terano A, Tabuchi M, et al: The comparison with rapid urease test and histological examination in detection of Helicobacter-pylori. Gastroenterol Endosco. 40:773–778. 1998.
12.	Smith SB, Snow AN, Perry RL and Qasem SA: Helicobacter pylori: to stain or not to stain? Am J Clin Pathol. 137:733–838. 2012. View Article : Google Scholar
13.	Kimura K and Takemoto T: An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy. 3:87–97. 1969. View Article : Google Scholar
14.	Yagi K, Nakamura A and Sekine A: Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylori infection. J Gastroenterol Hepatol. 17:39–45. 2002. View Article : Google Scholar : PubMed/NCBI
15.	Tanaka H, Ichikawa K, Fujimori T, et al: Diagnostic validity of DNMT-1 and 3b immunoreactivity in non-neoplastic epithelium of UC patients with and without neoplasia. DJMS. 39:29–35. 2012.
16.	Laine L, Cohen H, Sloane R, et al: Interobserver agreement and predictivevalue of endoscopic findings for H. pylori and gastritis in normal volunteers. Gastrointest Endosc. 42:420–423. 1995. View Article : Google Scholar : PubMed/NCBI
17.	Khakoo SI, Lobo AJ, Shepherd NA and Wilkinson SP: Histological assessment of the Sydney classification of endoscopic gastritis. Gut. 35:1172–1175. 1994. View Article : Google Scholar : PubMed/NCBI
18.	Bah A, Saraga E, Armstrong D, et al: Endoscopic features of Helicobacter pylori-related gastritis. Endoscopy. 27:593–596. 1995.
19.	Yagi K, Aruga Y, Nakamura A and Sekine A: Regular arrangement of collecting venules (RAC): a characteristic endoscopic feature of Helicobacter pylori-negative normal stomach and its relationship with esophago-gastric adenocarcinoma. J Gastroenterol. 40:443–452. 2005. View Article : Google Scholar : PubMed/NCBI
20.	Nakayama Y, Horiuchi A, Kumagai T, et al: Discrimination of normal gastric mucosa from Helicobacter pylori gastritis using standard endoscopes and a single observation site: studies in children and young adults. Helicobacter. 9:95–99. 2004.PubMed/NCBI
21.	Anagnostopoulos GK, Yao K, Kaye P, et al: High-resolution magnification endoscopy can reliably identify normal gastric mucosa, Helicobacter pylori-associated gastritis, and gastric atrophy. Endoscopy. 39:202–207. 2007. View Article : Google Scholar : PubMed/NCBI
22.	Machado RS, Viriato A, Kawakami E and Patricio FR: The regular arrangement of collecting venules pattern evaluated by standard endoscope and the absence of antrum nodularity are highly indicative of Helicobacter pylori uninfected gastric mucosa. Dig Liver Dis. 40:68–72. 2008. View Article : Google Scholar : PubMed/NCBI
23.	Gonen C, Simsek I, Sarioglu S and Akpinar H: Comparison of high resolution magnifying endoscopy and standard videoendoscopy for the diagnosis of Helicobacter pylori gastritis in routine clinical practice: a prospective study. Helicobacter. 14:12–21. 2009. View Article : Google Scholar : PubMed/NCBI
24.	Alaboudy A, Elbahrawy A, Matsumoto S, et al: Regular arrangement of collecting venules: Does patient age affect its accuracy? World J Gastrointest Endosc. 3:118–123. 2011. View Article : Google Scholar : PubMed/NCBI
25.	Okubo M, Tahara T, Shibata T, et al: Usefulness of magnifying narrow-band imaging endoscopy in the Helicobacter pylori-related chronic gastritis. Digestion. 83:161–166. 2011. View Article : Google Scholar : PubMed/NCBI
26.	Asaka M, Kato M, Takahashi S, et al: Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition. Helicobacter. 15:1–20. 2010.