A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis

Wu,Jin; Guan,Xuan; Zhang,Kui; Li,Ya‑Ting; Bai,Peng; Wu,Jin

doi:10.3892/br.2013.131

A/G polymorphism of matrix metalloproteinase 7 gene promoter region and cancer risk: A meta‑analysis

Authors:
- Jin Wu
- Xuan Guan
- Kui Zhang
- Ya‑Ting Li
- Peng Bai
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Affiliations: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: July 11, 2013 https://doi.org/10.3892/br.2013.131
Pages: 792-796

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Abstract

This meta‑analysis was conducted to evaluate the effect of the matrix metalloproteinase 7 (MMP7)‑181A/G polymorphism on cancer risk. Twenty‑seven case‑control studies were identified via a literature search through PubMed, web of science and China National Knowledge Infrastructure databases. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were applied to assess the strength of the association between MMP7‑181A/G polymorphism and cancer risk. The 27 studies were further assessed according to Hardy‑Weinberg equilibrium (HWE) and Hardy‑Weinberg disequilibrium (HWD), with 24 case‑control studies found to be under HWE. A significant association was observed between MMP7‑181A̸G polymorphism and increased cancer risk (cervical and other types of cancer) in Asian, but not in European populations.

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