Interleukin‑13 and its receptors in colorectal cancer (Review)

  • Authors:
    • Ru Zhou
    • Shiguang Qian
    • Xiaodong Gu
    • Zongyou Chen
    • Jianbin Xiang
  • View Affiliations

  • Published online on: July 11, 2013     https://doi.org/10.3892/br.2013.132
  • Pages: 687-690
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Abstract

Interleukin (IL)‑13 is an immunoregulatory cytokine secreted by numerous immune cells. Its functions are similar to those of IL‑4 and they share a common receptor. This cytokine has been included in recent studies on human tumors and malignant diseases, evoking a scientific interest to investigate the role of IL‑13 and its receptors as novel biomarkers and targets for therapy. Colorectal cancer is one of the most common human malignancies, its prognosis is not promising and the efficacy of molecular‑targeted therapy has not been established. This review summarizes the currently available data on the role of IL‑13 and its receptors in colorectal cancer, including the signaling pathways involved in mediating the effects of IL‑13, the role of IL‑13 and/or its receptors in the prediction of cancer and several drugs targeting IL‑13 or its receptors that are currently under evaluation.
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September-October 2013
Volume 1 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou R, Qian S, Gu X, Chen Z and Xiang J: Interleukin‑13 and its receptors in colorectal cancer (Review). Biomed Rep 1: 687-690, 2013
APA
Zhou, R., Qian, S., Gu, X., Chen, Z., & Xiang, J. (2013). Interleukin‑13 and its receptors in colorectal cancer (Review). Biomedical Reports, 1, 687-690. https://doi.org/10.3892/br.2013.132
MLA
Zhou, R., Qian, S., Gu, X., Chen, Z., Xiang, J."Interleukin‑13 and its receptors in colorectal cancer (Review)". Biomedical Reports 1.5 (2013): 687-690.
Chicago
Zhou, R., Qian, S., Gu, X., Chen, Z., Xiang, J."Interleukin‑13 and its receptors in colorectal cancer (Review)". Biomedical Reports 1, no. 5 (2013): 687-690. https://doi.org/10.3892/br.2013.132