Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta‑analysis
- Authors:
- Mengmeng Zhao
- Xuelian Li
- Chengzhong Xing
- Baosen Zhou
-
Affiliations: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Anorectal Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China - Published online on: July 15, 2013 https://doi.org/10.3892/br.2013.134
- Pages: 781-791
This article is mentioned in:
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Pardini B, Kumar R, Naccarati A, Prasad RB, Forsti A, Polakova V, Vodickova L, Novotny J, Hemminki K and Vodicka P: MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic. Mutat Res. 721:74–80. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cao HX, Gao CM, Takezaki T, Wu JZ, Ding JH, Liu YT, Li SP, Su P, Cao J, Hamajima N and Tajima K: Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer. Asian Pac J Cancer Prev. 9:203–208. 2008.PubMed/NCBI | |
|
Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar | |
|
Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB and Ames BN: Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA. 94:3290–3295. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Choi SW and Mason JB: Folate and carcinogenesis: an integrated scheme. J Nutr. 130:129–132. 2000.PubMed/NCBI | |
|
Cui LH, Shin MH, Kweon SS, Kim HN, Song HR, Piao JM, Choi JS, Shim HJ, Hwang JE, Kim HR, et al: Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population. BMC Cancer. 10:2362010. View Article : Google Scholar : PubMed/NCBI | |
|
Goyette P, Sumner JS, Milos R, Duncan AM, Rosenblatt DS, Matthews RG and Rozen R: Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet. 7:195–200. 1994. View Article : Google Scholar | |
|
Pereira AC, Schettert IT, Morandini Filho AA, Guerra-Shinohara EM and Krieger JE: Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population. Clin Chim Acta. 340:99–105. 2004. View Article : Google Scholar | |
|
Ogino S and Wilson RB: Genotype and haplotype distributions of MTHFR677C>T and 1298A>C single nucleotide polymorphisms: a meta-analysis. J Hum Genet. 48:1–7. 2003.PubMed/NCBI | |
|
Chen J, Giovannucci E, Kelsey K, et al: A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res. 56:4862–4864. 1996.PubMed/NCBI | |
|
van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP and Blom HJ: A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 62:1044–1051. 1998.PubMed/NCBI | |
|
Keku T, Millikan R, Worley K, Winkel S, Eaton A, Biscocho L, Martin C and Sandler R: 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev. 11:1611–1621. 2002.PubMed/NCBI | |
|
Heijmans BT, Boer JM, Suchiman HE, Cornelisse CJ, Westendorp RG, Kromhout D, Feskens EJ and Slagboom PE: A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer. Cancer Res. 63:1249–1253. 2003.PubMed/NCBI | |
|
Shannon B, Gnanasampanthan S, Beilby J and Iacopetta B: A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut. 50:520–524. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Yin G, Kono S, Toyomura K, Hagiwara T, Nagano J, Mizoue T, Mibu R, Tanaka M, Kakeji Y, Maehara Y, et al: Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. Cancer Sci. 95:908–913. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ma J, Stampfer MJ, Giovannucci E, et al: Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res. 57:1098–1102. 1997.PubMed/NCBI | |
|
Ryan BM, Molloy AM, McManus R, Arfin Q, Kelleher D, Scott JM and Weir DG: The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression. Int J Gastrointest Cancer. 30:105–111. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Sachse C, Smith G, Wilkie MJ, Barrett JH, Waxman R, Sullivan F, Forman D, Bishop DT and Wolf CR; Colorectal Cancer Study Group. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis. 23:1839–1849. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Pufulete M, Al-Ghnaniem R, Leather AJ, Appleby P, Gout S, Terry C, Emery PW and Sanders TA: Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology. 124:1240–1248. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Plaschke J, Schwanebeck U, Pistorius S, Saeger HD and Schackert HK: Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability. Cancer Lett. 191:179–185. 2003. View Article : Google Scholar | |
|
Toffoli G, Gafà R, Russo A, Lanza G, Dolcetti R, Sartor F, Libra M, Viel A and Boiocchi M: Methylenetetrahydrofolate reductase 677 C → T polymorphism and risk of proximal colon cancer in north Italy. Clin Cancer Res. 9:743–748. 2003. | |
|
Ulvik A, Vollset SE, Hansen S, Gislefoss R, Jellum E and Ueland PM: Colorectal cancer and the methylenetetrahydrofolate reductase 677C → T and methionine synthase 2756A → G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. Cancer Epidemiol Biomarkers Prev. 13:2175–2180. 2004. | |
|
Landi S, Gemignani F, Moreno V, Gioia-Patricola L, Chabrier A, Guino E, Navarro M, de Oca J, Capellà G and Canzian F; Bellvitge Colorectal Cancer Study Group. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. Pharmacogenet Genomics. 15:535–546. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Koushik A, Kraft P, Fuchs CS, Hankinson SE, Willett WC, Giovannucci EL and Hunter DJ: Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer. Cancer Epidemiol Biomarkers Prev. 15:2408–2017. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Stenling R, Riboli E, Winkvist A and Palmqvist R: Low folate levels may protect against colorectal cancer. Gut. 55:1461–1466. 2006.PubMed/NCBI | |
|
Battistelli S, Vittoria A, Stefanoni M, Bing C and Roviello F: Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. World J Gastroenterol. 12:6128–6132. 2006.PubMed/NCBI | |
|
Osian G, Procopciuc L and Vlad L: MTHFR polymorphisms as prognostic factors in sporadic colorectal cancer. J Gastrointestin Liver Dis. 16:251–256. 2007.PubMed/NCBI | |
|
Lima CS, Nascimento H, Bonadia LC, Teori MT, Coy CS, Goes JR, Costa FF and Bertuzzo CS: Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma. Int J Colorectal Dis. 22:757–763. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, Barnetson RA, Porteous ME, Dunlop MG and Campbell H: Dietary vitamin B6 intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 17:171–182. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Sharp L, Little J, Brockton NT, Cotton SC, Masson LF, Haites NE and Cassidy J: Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake. Br J Nutr. 99:379–389. 2008. View Article : Google Scholar | |
|
Eklöf V, Van Guelpen B, Hultdin J, Johansson I, Hallmans G and Palmqvist R: The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. Scand J Clin Lab Invest. 68:393–401. 2008. | |
|
Küry S, Buecher B, Robiou-du-Pont S, Scoul C, Colman H, Le Neel T, Le Houérou C, Faroux R, Ollivry J, Lafraise B, Chupin LD, Sébille V and Bézieau S: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. BMC Cancer. 8:3262008.PubMed/NCBI | |
|
Derwinger K, Wettergren Y, Odin E, Carlsson G and Gustavsson B: A study of the MTHFR gene polymorphism C677T in colorectal cancer. Clin Colorectal Cancer. 8:43–48. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
de Vogel S, Wouters KA, Gottschalk RW, van Schooten FJ, de Goeij AF, de Bruïne AP, Goldbohm RA, van den Brandt PA, Weijenberg MP and van Engeland M: Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 18:3086–3096. 2009.PubMed/NCBI | |
|
Fernández-Peralta AM, Daimiel L, Nejda N, Iglesias D, Medina Arana V and González-Aguilera JJ: Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy. Int J Colorectal Dis. 25:141–151. 2010.PubMed/NCBI | |
|
Gallegos-Arreola MP, Garcia-Ortiz JE, Figuera LE, Puebla-Perez AM, Morgan-Villela G and Zuniga-Gonzalez GM: Association of the 677C → T polymorphism in the MTHFR gene with colorectal cancer in Mexican patients. Cancer Genomics Proteomics. 6:183–188. 2009. | |
|
Komlosi V, Hitre E, Pap E, Adleff V, Reti A, Szekely E, Biro A, Rudnai P, Schoket B, Muller J, et al: SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer. BMC Cancer. 10:5252010. View Article : Google Scholar : PubMed/NCBI | |
|
Karpinski P, Myszka A, Ramsey D, Misiak B, Gil J, Laczmanska I, Grzebieniak Z, Sebzda T, Smigiel R, Stembalska A and Sasiadek MM: Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype. Cancer Epidemiol. 34:338–344. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Vossen CY, Hoffmeister M, Chang-Claude JC, Rosendaal FR and Brenner H: Clotting factor gene polymorphisms and colorectal cancer risk. J Clin Oncol. 29:1722–1727. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Eussen SJ, Vollset SE, Igland J, Meyer K, Fredriksen A, et al: Plasma folate, related genetic variants, and colorectal cancer risk in EPIC. Cancer Epidemiol Biomarkers Prev. 19:1328–1340. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JE, Wei EK, Fuchs CS, Hunter DJ, Lee IM, Selhub J, et al: Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies. Cancer Causes Control. 23:537–545. 2012. View Article : Google Scholar | |
|
Park KS, Mok JW and Kim JC: The 677C > T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk. Genet Test. 3:233–236. 1999. | |
|
Matsuo K, Hamajima N, Hirai T, Kato T, Inoue M, Takezaki T and Tajima K: Methionine synthase reductase gene A66G polymorphism is associated with risk of colorectal cancer. Asian Pac J Cancer Prev. 3:353–359. 2002.PubMed/NCBI | |
|
Huang P, Zhou ZY, Ma HT, Liu JY, Zhou YH, Cao J, Ge HY, Yu PW and Takezaki T: MTHFR polymorphisms and colorectal cancer susceptibility in Chongqing people. Acta Academiae Medicinae Militaris Tertiae. 25:1710–1713. 2003.(In Chinese). | |
|
Kim DH, Ahn YO, Lee BH, Tsuji E, Kiyohara C and Kono S: Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea. Cancer Lett. 216:199–205. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Matsuo K, Ito H, Wakai K, Hirose K, Saito T, Suzuki T, Kato T, Hirai T, Kanemitsu Y, Hamajima H and Tajima K: One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan. Carcinogenesis. 26:2164–2171. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang Q, Chen K, Ma X, Li Q, Yu W, Shu G and Yao K: Diets, polymorphisms of methylenetetrahydrofolate reductase, and the susceptibility of colon cancer and rectal cancer. Cancer Detect Prev. 29:146–154. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Miao XP, Yang S, Tan W, Zhang XM, et al: Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population. Chin J Prev Med. 39:409–411. 2005.(In Chinese). | |
|
Otani T, Iwasaki M, Hanaoka T, Kobayashi M, Ishihara J, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Yoshimura K, Yoshida T and Tsugane S: Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. Nutr Cancer. 53:42–50. 2005. View Article : Google Scholar | |
|
Wang J, Gajalakshmi V, Jiang J, Kuriki K, Suzuki S, Nagaya T, Nakamura S, Akasaka S, Ishikawa H and Tokudome S: Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and environmental factors with reference to susceptibility to colorectal cancer: a case-control study in an Indian population. Int J Cancer. 118:991–997. 2006. View Article : Google Scholar | |
|
Chang SC, Lin PC, Lin JK, Yang SH, Wang HS and Li AF: Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers. Int J Colorectal Dis. 22:483–489. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Zeybek U, Yaylim I, Yilmaz H, Agaçhan B, Ergen A, Arikan S, Bayrak S and Isbir T: Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer. Cell Biochem Funct. 25:419–422. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Jin XX, Zhu ZZ, Wang AZ and Jia HR: Association of methylenetetrahydrofolate reductase C677T polymorphism with genetic susceptibility to colorectal cancer. World Chin J Digestol. 15:2754–2757. 2007.(In Chinese). | |
|
Mokarram P, Naghibalhossaini F, Saberi Firoozi M, Hosseini SV, Izadpanah A, Salahi H, Malek-Hosseini SA, Talei A and Mojallal M: Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status. World J Gastroenterol. 14:3662–3671. 2008. View Article : Google Scholar | |
|
Haghighi MM, Radpour R, Mahmoudi T, Mohebbi SR, Vahedi M and Zali MR: Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer. Oncol Res. 18:57–63. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang YL, Yuan XY, Zhang Z, Yang H, Zhou YH, Pan YM, Zhou ZY, Liang HJ and Cao J: Relationship of genetic polymorphisms in methylenetetrahydrofolate reductase and alcohol drinking with the risk of colorectal cancer. Chin J Cancer Prev Treat. 15:1298–1301. 2008.(In Chinese). | |
|
Promthet SS, Pientong C, Ekalaksananan T, Wiangnon S, Poomphakwaen K, Songserm N, Chopjitt P, Moore MA and Tokudome S: Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors. J Epidemiol. 20:329–338. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Naghibalhossaini F, Mokarram P, Khalili I, Vasei M, Hosseini SV, Ashktorab H, Rasti M and Abdollahi K: MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients. Cancer Genet Cytogenet. 197:142–151. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kim JW, Park HM, Choi YK, Chong SY, Oh D and Kim NK: Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients. Oncol Rep. 25:167–172. 2011.PubMed/NCBI | |
|
Chandy S, Sadananda Adiga MN, Ramachandra N, Krishnamoorthy S, Ramaswamy G, Savithri HS and Krishnamoorthy L: Association of methylenetetrahydrofolate reductase gene polymorphisms and colorectal cancer in India. Indian J Med Res. 131:659–664. 2010.PubMed/NCBI | |
|
Zhu F, Wang YM and QY Z: A case-control study of plasma homocysteine, serum folate, the polymorphism of methylenetetrahydrofolate reductase in colorectal cancer. J Southeast Univ Med Sci Edi. 29:88–92. 2010. | |
|
Kang BS, Ahn DH, Kim NK and Kim JW: Relationship between metabolic syndrome and MTHFR polymorphism in colorectal cancer. J Korean Soc Coloproctol. 27:78–82. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Prasad VV and Wilkhoo H: Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancers. Onkologie. 34:422–426. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Sameer AS, Shah ZA, Nissar S, Mudassar S and Siddiqi MA: Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population. Genet Mol Res. 10:1200–1210. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Li H, Xu WL, Shen HL, Chen QY, Hui LL, Long LL and Zhu XL: Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population. Genet Mol Res. 10:3738–3746. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Yin G, Ming H, Zheng X, Xuan Y, Liang J and Jin X: Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study. Oncol Lett. 4:365–369. 2012.PubMed/NCBI | |
|
Kim J, Cho YA, Kim DH, Lee BH, Hwang DY, Jeong J, Lee HJ, Matsuo K, Tajima K and Ahn YO: Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea. Am J Clin Nutr. 95:405–412. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
El Awady MK, Karim AM, Hanna LS, El Husseiny LA, El Sahar M, Menem HA and Meguid NA: Methylenetetrahydrofolate reductase gene polymorphisms and the risk of colorectal carcinoma in a sample of Egyptian individuals. Cancer Biomark. 5:233–240. 2009.PubMed/NCBI | |
|
Guimarães JL, de Ayrizono ML, Coy CS and Lima CS: Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma. Tumour Biol. 32:853–861. 2011.PubMed/NCBI | |
|
Slattery ML, Potter JD, Samowitz W, Schaffer D and Leppert M: Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 8:513–518. 1999.PubMed/NCBI | |
|
Curtin K, Bigler J, Slattery ML, Caan B, Potter JD and Ulrich CM: MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 13:285–292. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Murtaugh MA, Curtin K, Sweeney C, Wolff RK, Holubkov R, Caan BJ and Slattery ML: Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. Cancer Causes Control. 18:153–163. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Iacopetta B, Heyworth J, Girschik J, Grieu F, Clayforth C and Fritschi L: The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer. Int J Cancer. 125:84–90. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Reeves SG, Meldrum C, Groombridge C, Spigelman AD, Suchy J, Kurzawski G, Lubinski J, McElduff P and Scott RJ: MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer. Eur J Hum Genet. 17:629–635. 2009. | |
|
Yang XX, Li FX, Yi J, Li X, Sun JZ and Hu NY: An association of methylenetetrahydrofolate reductase reductase C677T and gastric cancer, colorectal cancer and lung cancer susceptibility. Guangdong Med J. 31:2375–2377. 2010.(In Chinese). | |
|
Zhu Q, Jin Z, Yuan Y, Lu Q, Ge D and Zong M: Impact of MTHFR gene C677T polymorphism on Bcl-2 gene methylation and protein expression in colorectal cancer. Scand J Gastroenterol. 46:436–445. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Le Marchand L, Wilkens LR, Kolonel LN and Henderson BE: The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 14:1198–1203. 2005.PubMed/NCBI |
