Clinical value of circulating liver cancer cells for the diagnosis of hepatocellular carcinoma: A meta-analysis
- Authors:
- Tao Jin
- Hao Peng
- Hongyan Wu
View Affiliations
Affiliations: Department of Orthopedics, Renmin Hospital of Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Immunology, Medical College of Three Gorges University, Yichang, Hubei 443002, P.R. China
- Published online on: July 18, 2013 https://doi.org/10.3892/br.2013.139
-
Pages:
731-736
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
This meta‑analysis was conducted to evaluate the clinical value of circulating tumor cells (CTCs) for liver tumor size, clinical stage and metastasis. the clinical studies on CTCs and liver cancer were electronically and manually retrieved and Review Manager 5.1 software was used to evaluate the quality of the obtained studies, extract data and conduct a meta‑analysis. a total of 5 studies including 535 liver cancer patients were identified. The results of the meta‑analysis revealed that the odds ratio (OR) values of CTCs‑positive rates between large and small tumor size, tumor stage Ⅰ/Ⅱ and Ⅲ/Ⅳ, as well as metastatic and non‑metastatic groups were 12.12 (95% CI: 7.84‑18.74), 0.10 (95% CI: 0.07‑0.16) and 0.09 (95% CI: 0.05‑0.15), respectively, which demonstrated a significant difference. In conclusion, the detection of CTCs in the peripheral blood was clearly associated with tumor size, clinical stage and metastasis.
View Figures |
Figure 1
|
 |
Figure 2
|
 |
Figure 3
|
 |
Figure 4
|
 |
Figure 5
|
 |
Figure 6
|
View References
|
1
|
Ashworth TR: A case of cancer in which
cells similar to those in the tumors were seen in the blood after
death. Aus Med J. 14:146–149. 1869.
|
|
2
|
Alemar J and Schuur ER: Progress in using
circulating tumor cell information to improve metastatic breast
cancer therapy. J Oncol. 2013:7027322013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ren C, Chen H, Han C, et al: Detection and
molecular analysis of circulating tumor cells for early diagnosis
of pancreatic cancer. Med Hypotheses. 80:833–836. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Andreopoulou E and Cristofanilli M:
Circulating tumor cells as prognostic marker in metastatic breast
cancer. Expert Rev Anticancer Ther. 10:171–177. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Cohen SJ, Punt CJ, Iannotti N, et al:
Relationship of circulating tumor cells to tumor response,
progression-free survival, and overall survival in patients with
metastatic colorectal cancer. Clin Oncol. 26:3213–3221. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sun YF, Yang XR, Zhou J, Qiu SJ, Fan J and
Xu Y: Circulating tumor cells: advances in detection methods,
biological issues, and clinical relevance. J Cancer Res Clin Oncol.
137:1151–1173. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Liu D: Detection of circulating tumor
cells in peripheral blood and its significance in patients with
hepatocellular carcinoma (unpublished PhD thesis). Fudan
University. 2007.
|
|
8
|
Zuo GH: Detection and biological
characteristics of circulating tumor cells in peripheral blood of
patients with liver cancer (unpublished PhD thesis). Third Military
Med Univ. 2008.
|
|
9
|
Yu F: Improvement of circulating liver
cancer cells detection and its preliminary study on the
postoperative recurrence prediction (unpublished PhD thesis).
Second Military Med Univ. 2011.
|
|
10
|
Xu W: Isolation/detection system and
clinical application research of circulating liver cancer cells
based on sialic acid glycoprotein receptor (unpublished PhD
thesis). Second Military Med Univ. 2010.
|
|
11
|
Vona G, Estepa L, Béroud C, et al: Impact
of cytomorphological detection of circulating tumor cells in
patients with liver cancer. Hepatology. 39:792–797. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Ghossein R and Bhattacharya S: Molecular
detection and characterization of circulating tumor cells and
micrometastases in prostatic, urothelial, and renal cell
carcinomas. Semin Surg Oncol. 20:304–311. 2001. View Article : Google Scholar : PubMed/NCBI
|
