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Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation

  • Authors:
    • Naiju Zhang
    • Tianping Chen
    • Chunfang Liu
    • Bi Tang
    • Ling Nie
    • Huiling An
    • Duilan Zhao
    • Li Pan
    • Meiling Yu

  • View Affiliations

  • Published online on: September 12, 2013     https://doi.org/10.3892/br.2013.165
  • Pages: 935-939
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Abstract

Myocardial infarction (MI) may induce severe alterations of the cardiac contractile function that may, in turn, lead to heart failure (HF). The ubiquitin‑proteasome system (UPS) plays a critical role in cardiac remodeling following MI. Angiotensin II type 1 receptor (AT1R) blockers effectively prevent left ventricular (LV) remodeling. However, it has not been elucidated whether the preventive effect of AT1R‑blockers on LV remodeling is mediated through the UPS pathway. In the present study, with the use of cardiac morphometric parameters, haemodynamic measurements and enzyme‑linked immunosorbent assay, we demonstrated that post‑ischemic HF rats exhibited a significant increase in ventricular remodeling and irbesartan was effective in reversing cardiac remodeling. The expression of TNF‑α, ubiquitin protein and 20S proteasome were significantly increased in the MI control group and irbesartan was shown to dose‑dependently inhibit the expression of TNF‑α, ubiquitin protein and 20S proteasome. In conclusion, it was hypothesized that UPS signaling is involved in ventricular remodeling following MI and the mechanism underlying the effect of irbesartan on ventricular remodeling may be associated with the downregulation of the expression of TNF‑α, ubiquitin protein and 20S proteasome.
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November-December 2013
Volume 1 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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  • Journal Metrics
  • Impact Factor: 2.3
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  • CiteScore: 4.1
  • CiteScore Rank: Q1: #19/80 Pharmacology, Toxicology and Pharmaceutics
  • Source Normalized Impact per Paper (SNIP): 0.7
  • SCImago Journal Rank (SJR): 0.514
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Spandidos Publications style
Zhang N, Chen T, Liu C, Tang B, Nie L, An H, Zhao D, Pan L and Yu M: Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation. Biomed Rep 1: 935-939, 2013.
APA
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H. ... Yu, M. (2013). Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation. Biomedical Reports, 1, 935-939. https://doi.org/10.3892/br.2013.165
MLA
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H., Zhao, D., Pan, L., Yu, M."Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation". Biomedical Reports 1.6 (2013): 935-939.
Chicago
Zhang, N., Chen, T., Liu, C., Tang, B., Nie, L., An, H., Zhao, D., Pan, L., Yu, M."Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post‑infarction ventricular remodeling and decreases TNF‑α generation". Biomedical Reports 1, no. 6 (2013): 935-939. https://doi.org/10.3892/br.2013.165