The emerging role of interleukin‑21 in allergic diseases (Review)

Gong,Fang; Su,Qiang; Pan,Yu Hong; Huang,Xuan; Shen,Wei Hong

doi:10.3892/br.2013.166

The emerging role of interleukin‑21 in allergic diseases (Review)

Authors:
- Fang Gong
- Qiang Su
- Yu Hong Pan
- Xuan Huang
- Wei Hong Shen
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Affiliations: Department of Laboratory Medicine, Allergy and Clinical Immunology, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China, Department of Pulmonary Medicine, Allergy and Clinical Immunology, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China
Published online on: September 12, 2013 https://doi.org/10.3892/br.2013.166
Pages: 837-839

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Abstract

Interleukin (IL)‑21 is a newly discovered member of the type I cytokine family. Since its discovery in 2000, IL‑21 has been the focus of extensive investigation, due to its homology to IL‑2, IL‑4 and IL‑15 and its pleiotropic effects on innate and adaptive immune responses. an increasing amount of experimental evidence supports a role for IL‑21 in the pathogenesis of several allergic diseases, such as allergic rhinitis, atopic dermatitis (AD) and atopic asthma. In this review, we aimed to discuss the biological characteristics of IL‑21 and summarize the current progress on the role of IL‑21 in the regulation of allergic inflammation.

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