Structure and function of IQ‑domain GTPase‑activating protein 1 and its association with tumor progression (Review)

  • Authors:
    • Yan Wu
    • Yong‑Chang Chen
  • View Affiliations

  • Published online on: November 20, 2013     https://doi.org/10.3892/br.2013.204
  • Pages: 3-6
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Abstract

IQ‑domain GTPase‑activating proteins (IQGAPs) are evolutionary conserved multidomain proteins that are found in numerous organisms, from yeast to mammals. To date, three IQGAP proteins have been identified in humans, of which IQGAP1 is the best characterized. As a scaffold protein, IQGAP1 contains multiple protein‑interacting domains, which modulate binding to target proteins. Recent mounting studies demonstrated a role for IQGAP1 in tumor progression, supported by the altered expression and subcellular distribution of IQGAP1 in tumors. The contribution of IQGAP1 to tumor progression appears to involve a complex interplay of cell functions by integrating diverse signal transduction pathways and coordinating activities, such as cell adhesion, migration, invasion, proliferation and angiogenesis.
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January-February 2014
Volume 2 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Wu Y and Chen YC: Structure and function of IQ‑domain GTPase‑activating protein 1 and its association with tumor progression (Review). Biomed Rep 2: 3-6, 2014.
APA
Wu, Y., & Chen, Y. (2014). Structure and function of IQ‑domain GTPase‑activating protein 1 and its association with tumor progression (Review). Biomedical Reports, 2, 3-6. https://doi.org/10.3892/br.2013.204
MLA
Wu, Y., Chen, Y."Structure and function of IQ‑domain GTPase‑activating protein 1 and its association with tumor progression (Review)". Biomedical Reports 2.1 (2014): 3-6.
Chicago
Wu, Y., Chen, Y."Structure and function of IQ‑domain GTPase‑activating protein 1 and its association with tumor progression (Review)". Biomedical Reports 2, no. 1 (2014): 3-6. https://doi.org/10.3892/br.2013.204