Effects of aging on the plasma levels of nesfatin‑1 and adiponectin

Li,Jiang-Bo; Nishida,Miyuki; Kaimoto,Kaori; Asakawa,Akihiro; Chaolu,Huhe; Cheng,Kai-Chun; Li,Ying-Xiao; Terashi,Mutsumi; Koyama,Ken  Ichiro; Amitani,Haruka; Sakoguchi,Takeo; Ushikai,Miharu; Ikeda,Satoshi; Aoyama,Kohji; Horiuchi,Masahisa; Li,Jian-Zhong; Inui,Akio

doi:10.3892/br.2013.206

Effects of aging on the plasma levels of nesfatin‑1 and adiponectin

Authors:
- Jiang-Bo Li
- Miyuki Nishida
- Kaori Kaimoto
- Akihiro Asakawa
- Huhe Chaolu
- Kai-Chun Cheng
- Ying-Xiao Li
- Mutsumi Terashi
- Ken Ichiro Koyama
- Haruka Amitani
- Takeo Sakoguchi
- Miharu Ushikai
- Satoshi Ikeda
- Kohji Aoyama
- Masahisa Horiuchi
- Jian-Zhong Li
- Akio Inui
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Affiliations: Department of Social and Behavioral Medicine, Division of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Department of Human and Environmental Sciences, Division of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, Department of Neuromusculoskeletal Disorders, Division of Rehabilitation and Physical Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan, College of Psychology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China
Published online on: November 22, 2013 https://doi.org/10.3892/br.2013.206
Pages: 152-156

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Abstract

Gastric and adipose tissue secrete a number of hormones that are involved in energy metabolism. The biological functions of these hormones, including their effects on aging, are currently under investigation. Adiponectin was shown to be directly involved in appetite and the control of body weight. However, the effects of aging of nesfatin‑1, an appetite‑suppressing peptide that was recently identified, have not yet been fully elucidated. The aim of this study was to determine the effects of aging on the plasma levels of nesfatin‑1 and adiponectin. Our results demonstrated no significant differences in the nesfatin‑1 plasma levels among three age groups (2, 6 and 24 months) of female BALB̸c mice. The plasma nesfatin‑1 levels̸visceral fat (VF) ratio in the 24‑month‑old mice was significantly lower compared to that in the 2‑ and 6‑month‑old mice. In addition, there were no significant differences in the plasma adiponectin levels among the three age groups. The plasma adiponectin levels̸VF ratio in the 24‑month‑old mice was significantly lower compared to that in the 2‑ and 6‑month‑old mice. In conclusion, there were no age‑related changes in the plasma levels of nesfatin‑1 and adiponectin, although the ratio of plasma levels of nesfatin‑1 and adiponectin per VF was decreased with advancing age. Our results indicated that nesfatin‑1 and adiponectin may be involved in controlling energy balance during aging.

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