The regulatory role of immunosuppressants on immune abnormalities in acute pancreatitis

  • Authors:
    • Ligeng Duan
    • Yu Ma
    • Junlin Chi
    • Xu Wang
    • Alexander J. Wesley
    • Xiaoli Chen
  • View Affiliations

  • Published online on: November 29, 2013     https://doi.org/10.3892/br.2013.208
  • Pages: 193-198
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Abstract

The uncontrolled progression of the inflammatory cascade is the main cause underlying the development of multiple organ dysfunction syndrome (MODS) in acute pancreatitis. In this study, we investigated the effects of several immunosuppressants on mitigating the systemic inflammatory reaction syndrome (SIRS) and the compensatory anti‑inflammatory response syndrome (CARS) associated with acute pancreatitis. A total of 93 male Sprague Dawley rats were divided into 5 groups: group 1 was the sham group and group 2 underwent laparoscopic intrapancreatic duct injection of sodium taurocholate to induce pancreatitis. The remaining 3 groups were the same as group 2, with the addition of methylprednisolone, cyclophosphamide or methotrexate treatment (metastab, CTX or MTX groups, respectively). Following establishment of the acute pancreatitis model, the serum levels of inflammatory and anti‑inflammatory cytokines in groups 2, 3, 4 and 5 were found to be significantly elevated. Following immunosuppressant administration, the levels of all inflammatory and anti‑inflammatory cytokines investigated in groups 3, 4 and 5 were decreased compared to those in group 2. The pancreatic amylase levels and pancreatic wet weight (PWW) were also decreased in groups 3, 4 and 5 compared to those in group 2. Therefore, immunosuppressants may reduce inflammation‑related cytokine levels in acute pancreatitis and relieve disease progression.
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March-April 2014
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Copy and paste a formatted citation
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Spandidos Publications style
Duan L, Ma Y, Chi J, Wang X, Wesley AJ and Chen X: The regulatory role of immunosuppressants on immune abnormalities in acute pancreatitis. Biomed Rep 2: 193-198, 2014.
APA
Duan, L., Ma, Y., Chi, J., Wang, X., Wesley, A.J., & Chen, X. (2014). The regulatory role of immunosuppressants on immune abnormalities in acute pancreatitis. Biomedical Reports, 2, 193-198. https://doi.org/10.3892/br.2013.208
MLA
Duan, L., Ma, Y., Chi, J., Wang, X., Wesley, A. J., Chen, X."The regulatory role of immunosuppressants on immune abnormalities in acute pancreatitis". Biomedical Reports 2.2 (2014): 193-198.
Chicago
Duan, L., Ma, Y., Chi, J., Wang, X., Wesley, A. J., Chen, X."The regulatory role of immunosuppressants on immune abnormalities in acute pancreatitis". Biomedical Reports 2, no. 2 (2014): 193-198. https://doi.org/10.3892/br.2013.208