Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer

  • Authors:
    • Takafumi Watanabe
    • Masahiko Shibata
    • Hiroshi Nishiyama
    • Shu Soeda
    • Shigenori Furukawa
    • Kenji Gonda
    • Seiichi Takenoshita
    • Keiya Fujimori
  • View Affiliations

  • Published online on: January 16, 2013     https://doi.org/10.3892/br.2013.54
  • Pages: 197-201
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Vascular endothelial growth factor (VEGF) reportedly plays an important role in the progression of malignant neoplasms. In the present study, measured serum concentrations of VEGF were measured in patients with ovarian cancer and correlations with nutritional damage and chronic inflammation were analyzed. A significant increase in serum levels in patients compared to healthy volunteers was observed. Levels of VEGF were inversely correlated with serum concentrations of prealbumin, transferrin and retinol‑binding protein. VEGF levels were also correlated with serum levels of c‑reactive protein (CRP), an effective marker of inflammation. CRP levels were significantly elevated in patients with stage III and IV disease and inversely correlated with serum concentrations of total protein, prealbumin, transferrin and retinol‑binding protein. These results demonstrated that an increased production of VEGF correlated with nutritional impairment and inflammation.
View Figures
View References

Related Articles

Journal Cover

March-April 2013
Volume 1 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Watanabe T, Shibata M, Nishiyama H, Soeda S, Furukawa S, Gonda K, Takenoshita S and Fujimori K: Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer. Biomed Rep 1: 197-201, 2013.
APA
Watanabe, T., Shibata, M., Nishiyama, H., Soeda, S., Furukawa, S., Gonda, K. ... Fujimori, K. (2013). Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer. Biomedical Reports, 1, 197-201. https://doi.org/10.3892/br.2013.54
MLA
Watanabe, T., Shibata, M., Nishiyama, H., Soeda, S., Furukawa, S., Gonda, K., Takenoshita, S., Fujimori, K."Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer". Biomedical Reports 1.2 (2013): 197-201.
Chicago
Watanabe, T., Shibata, M., Nishiyama, H., Soeda, S., Furukawa, S., Gonda, K., Takenoshita, S., Fujimori, K."Elevated serum levels of vascular endothelial growth factor is effective as a marker for malnutrition and inflammation in patients with ovarian cancer". Biomedical Reports 1, no. 2 (2013): 197-201. https://doi.org/10.3892/br.2013.54