The paradox of IL‑10‑mediated modulation in cervical cancer (Review)

  • Authors:
    • Yan Wang
    • Xiao‑Hong Liu
    • Yue‑Hong Li
    • Ou Li
  • View Affiliations

  • Published online on: February 26, 2013     https://doi.org/10.3892/br.2013.69
  • Pages: 347-351
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Abstract

Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent. The role of IL-10 in cervical cancer is also dual. Here, we review the IL-10‑mediated tumor-promoting effect and tumor-inhibiting effects in cervical cancer, among which, human papilloma virus (HPV), human leukocyte antigen-G (HLA-G) and IL-10 polymorphisms are associated with the development of cervical cancer. IL-10 is also used for the therapy of cervical cancer through enhancing proliferation, expression of immunologically important surface molecules and increasing Th1 cytokine production and cytotoxic potential in HPV-specific CD8 (+) cytotoxic T lymphocytes.
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May-June 2013
Volume 1 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Liu XH, Li YH and Li O: The paradox of IL‑10‑mediated modulation in cervical cancer (Review). Biomed Rep 1: 347-351, 2013.
APA
Wang, Y., Liu, X., Li, Y., & Li, O. (2013). The paradox of IL‑10‑mediated modulation in cervical cancer (Review). Biomedical Reports, 1, 347-351. https://doi.org/10.3892/br.2013.69
MLA
Wang, Y., Liu, X., Li, Y., Li, O."The paradox of IL‑10‑mediated modulation in cervical cancer (Review)". Biomedical Reports 1.3 (2013): 347-351.
Chicago
Wang, Y., Liu, X., Li, Y., Li, O."The paradox of IL‑10‑mediated modulation in cervical cancer (Review)". Biomedical Reports 1, no. 3 (2013): 347-351. https://doi.org/10.3892/br.2013.69