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Article

Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers

  • Authors:
    • Hidefumi Sasaki
    • Ayumi Suzuki
    • Masayuki Shitara
    • Yu Hikosaka
    • Katsuhiro Okuda
    • Satoru Moriyama
    • Motoki Yano
    • Yoshitaka Fujii
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467‑8601, Japan
  • Pages: 484-488
    |
    Published online on: March 19, 2013
       https://doi.org/10.3892/br.2013.83
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Abstract

The metabolism of xenobiotics plays a fundamental role in smoking‑related lung function loss and the development of pulmonary disease. An NRF2‑dependent response is a key protective mechanism against oxidative stress. In the present study, we evaluated the effect of single nucleotide polymorphisms in NRF2 genes on the level of forced expiratory volume in one second (FEV1) in lung cancers of smokers. We genotyped the status of NRF2 gene polymorphisms in 209 surgically treated lung cancer cases of smokers using TaqMan polymerase chain reaction (PCR). The results demonstrated the mean FEV1 in patients with rs2364723 C/C, C/G and G/G to be 2143.9, 2294.2 and 2335.4 ml, respectively, and there was a tendency towards lower FEV1 in C/C phenotype (P=0.0944). The mean FEV1 was significantly lower in the C/C phenotype (2143.9±566.0 ml) compared to C/G or G/G (2308.9±642.9 ml, P=0.05). The mean FEV1 in patients with rs6726395 A/A, G/A and G/G was 66.7, 71.2 and 72.3%, respectively, and there was a significant difference between A/A and G/G phenotype (P=0.043). A tendency towards a lower mean FEV1 in A/A phenotype (66.7±11.7%) was observed when compared to A/G or G/G (71.9±10.7%, P=0.07). This study demonstrated that an NRF2‑dependent response to cigarette smoking has the potential to affect FEV1 decrease in a lung cancer population. In conclusion, the results have shown that NRF2 genetic changes may play a role in FEV1 loss in smokers with lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Sasaki H, Suzuki A, Shitara M, Hikosaka Y, Okuda K, Moriyama S, Yano M and Fujii Y: Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers. Biomed Rep 1: 484-488, 2013.
APA
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S. ... Fujii, Y. (2013). Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers. Biomedical Reports, 1, 484-488. https://doi.org/10.3892/br.2013.83
MLA
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S., Yano, M., Fujii, Y."Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers". Biomedical Reports 1.3 (2013): 484-488.
Chicago
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S., Yano, M., Fujii, Y."Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers". Biomedical Reports 1, no. 3 (2013): 484-488. https://doi.org/10.3892/br.2013.83
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki H, Suzuki A, Shitara M, Hikosaka Y, Okuda K, Moriyama S, Yano M and Fujii Y: Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers. Biomed Rep 1: 484-488, 2013.
APA
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S. ... Fujii, Y. (2013). Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers. Biomedical Reports, 1, 484-488. https://doi.org/10.3892/br.2013.83
MLA
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S., Yano, M., Fujii, Y."Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers". Biomedical Reports 1.3 (2013): 484-488.
Chicago
Sasaki, H., Suzuki, A., Shitara, M., Hikosaka, Y., Okuda, K., Moriyama, S., Yano, M., Fujii, Y."Polymorphisms of NRF2 gene correlated with decreased FEV1 in lung cancers of smokers". Biomedical Reports 1, no. 3 (2013): 484-488. https://doi.org/10.3892/br.2013.83
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