CASP‑1, ‑2 and ‑5 gene polymorphisms and cancer risk: A review and meta‑analysis

Pan,Ying‑Li; Liu,Wei; Gao,Cai‑Xiang; Shang,Zuo; Ning,Li‑Juan; Liu,Xing

doi:10.3892/br.2013.98

CASP‑1, ‑2 and ‑5 gene polymorphisms and cancer risk: A review and meta‑analysis

Authors:
- Ying‑Li Pan
- Wei Liu
- Cai‑Xiang Gao
- Zuo Shang
- Li‑Juan Ning
- Xing Liu
View Affiliations

Affiliations: Department of Nursing, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China
Published online on: April 25, 2013 https://doi.org/10.3892/br.2013.98
Pages: 511-516

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Accumulating evidence suggests the CASP gene family is important in the development of carcinogenesis. These genetic polymorphisms have been extensively investigated as a potential risk factor for cancer, but results have been inconclusive. This Human Genome Epidemiology (HuGE) review and meta‑analysis was performed to investigate the associations between CASP‑1, ‑2 and ‑5 and cancer risk. A literature search of Pubmed, Embase, Web of Science and CBM databases was conducted from inception through September 1st, 2012. Four case‑control studies with a total of 1,592 cancer cases and 1,833 healthy controls were included in the present meta‑analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Five polymorphisms were examined, including rs501192 (G>A), rs4647297 (C>G), rs507879 (T>C), rs3181320 (G>C) and rs523104 (G>C). Meta‑analysis results showed that the rs3181320*C allele/carrier were associated with increased risk of various types of cancers (OR=1.26; 95% CI, 1.04‑1.54; P=0.020 and OR=1.33; 95% CI, 1.00‑1.75; P=0.047, respectively). However, similar associations were not found in the rs501192, rs4647297, rs507879 and rs523104 polymorphisms (all P>0.05). Results from the current meta‑analysis suggest that the rs3181320*C allele/carrier in CASP‑5 gene are potential risk factors for cancer.

View Figures

View References

1.	Ghavami S, Hashemi M, Ande SR, et al: Apoptosis and cancer: mutations within caspase genes. J Med Genet. 46:497–510. 2009. View Article : Google Scholar : PubMed/NCBI
2.	Dang TP: Notch, apoptosis and cancer. Adv Exp Med Biol. 727:199–209. 2012. View Article : Google Scholar : PubMed/NCBI
3.	Raff M: Cell suicide for beginners. Nature. 396:119–122. 1998. View Article : Google Scholar : PubMed/NCBI
4.	Shivapurkar N, Reddy J, Chaudhary PM and Gazdar AF: Apoptosis and lung cancer: a review. J Cell Biochem. 88:885–898. 2003. View Article : Google Scholar
5.	Hajra KM and Liu JR: Apoptosome dysfunction in human cancer. Apoptosis. 9:691–704. 2004. View Article : Google Scholar : PubMed/NCBI
6.	Son JW, Kang HK, Chae MH, et al: Polymorphisms in the caspase-8 gene and the risk of lung cancer. Cancer Genet Cytogenet. 169:121–127. 2006. View Article : Google Scholar : PubMed/NCBI
7.	Degterev A, Boyce M and Yuan J: A decade of caspases. Oncogene. 22:8543–8567. 2003. View Article : Google Scholar : PubMed/NCBI
8.	Kumar S and Dorstyn L: Analysing caspase activation and caspase activity in apoptotic cells. Methods Mol Biol. 559:3–17. 2009. View Article : Google Scholar : PubMed/NCBI
9.	Siegel RM: Caspases at the crossroads of immune-cell life and death. Nat Rev Immunol. 6:308–317. 2006. View Article : Google Scholar : PubMed/NCBI
10.	MacPherson G, Healey CS, Teare MD, et al: Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst. 96:1866–1869. 2004. View Article : Google Scholar : PubMed/NCBI
11.	Zhang X, Miao X, Sun T, et al: Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. J Med Genet. 42:479–484. 2005. View Article : Google Scholar : PubMed/NCBI
12.	Yang M, Sun T, Wang L, et al: Functional variants in cell death pathway genes and risk of pancreatic cancer. Clin Cancer Res. 14:3230–3236. 2008. View Article : Google Scholar : PubMed/NCBI
13.	Dong LM, Brennan P, Karami S, et al: An analysis of growth, differentiation and apoptosis genes with risk of renal cancer. PloS One. 4:e48952009. View Article : Google Scholar : PubMed/NCBI
14.	Mittal RD, Srivastava P, Mittal T, et al: Association of death receptor 4, caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians. Eur J Surg Oncol. 37:727–733. 2011. View Article : Google Scholar : PubMed/NCBI
15.	Ulybina YM, Kuligina ESh and Mitiushkina NV: et al Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer. Cancer Lett. 278:183–191. 2009. View Article : Google Scholar : PubMed/NCBI
16.	von Elm E, Altman DG, Egger M, et al: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Epidemiology. 18:800–804. 2007.
17.	Zhang L, Liu JL, Zhang YJ and Wang H: Association between HLA-B*27 polymorphisms and ankylosing spondylitis in Han populations: a meta-analysis. Clin Exp Rheumatol. 29:285–292. 2011.
18.	Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI
19.	Zintzaras E and Ioannidis JP: Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 28:123–137. 2005. View Article : Google Scholar : PubMed/NCBI
20.	Peters JL, Sutton AJ, Jones DR, et al: Comparison of two methods to detect publication bias in meta-analysis. JAMA. 295:676–680. 2006. View Article : Google Scholar : PubMed/NCBI
21.	Hart K, Landvik NE, Lind H, et al: A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer. Lung Cancer. 71:123–129. 2011. View Article : Google Scholar : PubMed/NCBI
22.	Mittal RD, Mittal T, Singh AK and Mandal RK: Association of caspases with an increased prostate cancer risk in north Indian population. DNA Cell Biol. 31:67–73. 2012. View Article : Google Scholar : PubMed/NCBI
23.	Kumar S: Measurement of caspase activity in cells undergoing apoptosis. Methods Mol Biol. 282:19–30. 2004.PubMed/NCBI
24.	Belogubova EV, Ulibina YM, Suvorova IK, et al: Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects. J Cancer Res Clin Oncol. 132:327–331. 2006. View Article : Google Scholar : PubMed/NCBI
25.	Soung YH, Jeong EG, Ahn CH, et al: Mutational analysis of caspase 1, 4, and 5 genes in common human cancers. Hum Pathol. 39:895–900. 2008. View Article : Google Scholar : PubMed/NCBI