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Article

Association of adiponectin +276G/T polymorphism with knee osteoarthritis

  • Authors:
    • Dong Zhan
    • Pongsak Yuktanandana
    • Wilai Anomasiri
    • Aree Tanavalee
    • Sittisak Honsawek
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
  • Pages: 229-232
    |
    Published online on: January 20, 2014
       https://doi.org/10.3892/br.2014.228
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Abstract

Osteoarthritis (OA) is a prevalent, degenerative joint disorder leading to the destruction of articular cartilage, osteophyte formation and subchondral bone sclerosis. Genetic and environmental factors are involved in the development of OA. The role of adiponectin gene polymorphisms in OA has not yet been established. The aim of this study was to investigate the association of adiponectin +276G/T (rs1501299) gene polymorphism with knee OA. Genotype distributions and allelic frequencies of adiponectin gene, +276G/T polymorphism were determined in a total of 200 subjects (100 knee OA patients and 100 healthy controls). Single‑nucleotide polymorphism (SNP) of the adiponectin +276G/T gene was genotyped by polymerase chain reaction (PCR)‑restriction fragment length polymorphism analysis. The genotype distribution of +276G/T SNP was observed in the Hardy‑Weinberg equilibrium for OA patients and controls. No statistically significant difference was identified between the two groups with respect to genotype distributions and allelic frequencies (P>0.05). The T‑ and G‑allele frequencies were indicated as 24.5 and 75.5%, respectively, in OA patients, whereas the frequency was 23‑70% in the control group. Findings of this study therefore suggest that the +276G/T SNP was not associated with susceptibility to knee OA.
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Copy and paste a formatted citation
Spandidos Publications style
Zhan D, Yuktanandana P, Anomasiri W, Tanavalee A and Honsawek S: Association of adiponectin +276G/T polymorphism with knee osteoarthritis. Biomed Rep 2: 229-232, 2014.
APA
Zhan, D., Yuktanandana, P., Anomasiri, W., Tanavalee, A., & Honsawek, S. (2014). Association of adiponectin +276G/T polymorphism with knee osteoarthritis. Biomedical Reports, 2, 229-232. https://doi.org/10.3892/br.2014.228
MLA
Zhan, D., Yuktanandana, P., Anomasiri, W., Tanavalee, A., Honsawek, S."Association of adiponectin +276G/T polymorphism with knee osteoarthritis". Biomedical Reports 2.2 (2014): 229-232.
Chicago
Zhan, D., Yuktanandana, P., Anomasiri, W., Tanavalee, A., Honsawek, S."Association of adiponectin +276G/T polymorphism with knee osteoarthritis". Biomedical Reports 2, no. 2 (2014): 229-232. https://doi.org/10.3892/br.2014.228
Copy and paste a formatted citation
x
Spandidos Publications style
Zhan D, Yuktanandana P, Anomasiri W, Tanavalee A and Honsawek S: Association of adiponectin +276G/T polymorphism with knee osteoarthritis. Biomed Rep 2: 229-232, 2014.
APA
Zhan, D., Yuktanandana, P., Anomasiri, W., Tanavalee, A., & Honsawek, S. (2014). Association of adiponectin +276G/T polymorphism with knee osteoarthritis. Biomedical Reports, 2, 229-232. https://doi.org/10.3892/br.2014.228
MLA
Zhan, D., Yuktanandana, P., Anomasiri, W., Tanavalee, A., Honsawek, S."Association of adiponectin +276G/T polymorphism with knee osteoarthritis". Biomedical Reports 2.2 (2014): 229-232.
Chicago
Zhan, D., Yuktanandana, P., Anomasiri, W., Tanavalee, A., Honsawek, S."Association of adiponectin +276G/T polymorphism with knee osteoarthritis". Biomedical Reports 2, no. 2 (2014): 229-232. https://doi.org/10.3892/br.2014.228
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