Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta‑analysis of 15 genetic association studies

Dai,Dongjun; Lin,Peipei; Wang,Yunliang; Zhou,Xingyu; Tao,Jianmin; Jiang,Danjie; Zhou,Hanlin; Ru,Ping; Pan,Guanghui; Li,Jinfeng; Zhang,Yuzheng; Yin,Honglei; Duan,Shiwei

doi:10.3892/br.2014.296

Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta‑analysis of 15 genetic association studies

Authors:
- Dongjun Dai
- Peipei Lin
- Yunliang Wang
- Xingyu Zhou
- Jianmin Tao
- Danjie Jiang
- Hanlin Zhou
- Ping Ru
- Guanghui Pan
- Jinfeng Li
- Yuzheng Zhang
- Honglei Yin
- Shiwei Duan
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Affiliations: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Department of Neurology, 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China
Published online on: June 16, 2014 https://doi.org/10.3892/br.2014.296
Pages: 713-718

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Abstract

Parkinson's disease (PD) is a neurodegenerative movement d’isorder that affects ~2% of the population aged ≥65 years. NAD(P)H‑quinone oxidoreductase 1 (NQO1) and tumor necrosis factor‑α (TNF‑α) are two important factors in the generation of oxidative stress in PD. The aim of the present study was to assess the association of NQO1 and tumor necrosis factor (TNF) polymorphisms with PD. A meta‑analysis was performed that included data from 15 studies comprising 2,858 patients and 2,907 healthy controls. The results showed that TNF‑1031 (rs1799964) was significantly associated with PD in the recessive [P=0.0005; odds ratio (OR), 3.19; 95% confidence interval (CI), 1.66‑6.13] and additive models (P=0.0006; OR, 3.15; 95% CI, 1.63‑3.51). However, there was no significant association in NQO1 C609T (rs1800566) and TNF‑308 (rs1800629) with PD. To the best of our knowledge, the present study is the first meta‑analysis of NQO1 and TNF polymorphisms with PD demonstrating that TNF‑1031 polymorphism may be a risk factor for PD under either the recessive or additive models. However, the meta‑analyses did not support the involvement of NQO1 C609T and TNF‑308 in the risk of PD.

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