Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2

  • Authors:
    • Xulong Lang
    • Zhonghai Wan
    • Zhaoyang Bu
    • Xiuran Wang
    • Xiaoxu Wang
    • Lingwei Zhu
    • Jiayu Wan
    • Yang Sun
    • Xinglong Wang
  • View Affiliations

  • Published online on: June 30, 2014     https://doi.org/10.3892/br.2014.307
  • Pages: 709-712
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Abstract

Streptococcus suis (S. suis) type 2 is an extremely important Gram‑positive bacterial pathogen that can cause human or swine endocarditis, meningitis, bronchopneumonia, arthritis and sepsis. Catabolite control protein A (CcpA) is a major transcriptional regulator in S. suis type 2 that functions in catabolite control, specifically during growth on glucose or galactose. The regulation of central metabolism can affect the virulence of bacteria. In the present study, a metabolomics approach was used along with principal components analysis (PCA) and partial least-squares‑discriminant analysis (PLS‑DA) models and 37 metabolites were found that differed substantially between native S. suis and a mutant lacking CcpA. These results showed that CcpA is an important protein in S. suis type 2 for studying bacterial protein function.
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September-October 2014
Volume 2 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Lang X, Wan Z, Bu Z, Wang X, Wang X, Zhu L, Wan J, Sun Y and Wang X: Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2. Biomed Rep 2: 709-712, 2014
APA
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L. ... Wang, X. (2014). Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2. Biomedical Reports, 2, 709-712. https://doi.org/10.3892/br.2014.307
MLA
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2". Biomedical Reports 2.5 (2014): 709-712.
Chicago
Lang, X., Wan, Z., Bu, Z., Wang, X., Wang, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A is an important regulator of metabolism in Streptococcus suis type 2". Biomedical Reports 2, no. 5 (2014): 709-712. https://doi.org/10.3892/br.2014.307