Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction

  • Authors:
    • Weijie Wang
    • Yujiao Zhang
    • Mei Gao
    • Jiangrong Wang
    • Yinglong Hou
  • View Affiliations

  • Published online on: September 26, 2014     https://doi.org/10.3892/br.2014.366
  • Pages: 78-82
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Abstract

The present study aimed to investigate the effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction (MI). The rabbits were randomly divided into 4 groups: The sham operation group (S; n=8), the MI group (MI; n=7), the group with low‑dose rosuvastatin [Rs; 2.5 mg/(kg/d), n=7] and the group with high‑dose rosuvastatin [Rl, 5 mg/(kg/d), n=8]. A rabbit MI model was established via ligation of the anterior descending coronary artery. After 8 weeks of intervention, the left atrial diameter (LAD), atrial collagen content, expression level of type Ⅰ collagen and left ventricular ejection fraction (LVEF) were measured. LAD in the MI group was significantly larger than the S, Rs and Rl groups after 8 weeks. The left atrial collagen content of the MI group was also significantly greater than those observed in the other 3 groups. The expression of type Ⅰ collagen in the MI group was significantly increased compared to the other 3 groups. However, LVEF of the MI group was lower compared to the other 3 groups. There were no significant differences between the Rs and Rl groups in the above indexes. In conclusion, rosuvastatin can improve post‑MI atrial structural remodeling.
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Copy and paste a formatted citation
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Spandidos Publications style
Wang W, Zhang Y, Gao M, Wang J and Hou Y: Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction. Biomed Rep 3: 78-82, 2015.
APA
Wang, W., Zhang, Y., Gao, M., Wang, J., & Hou, Y. (2015). Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction. Biomedical Reports, 3, 78-82. https://doi.org/10.3892/br.2014.366
MLA
Wang, W., Zhang, Y., Gao, M., Wang, J., Hou, Y."Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction". Biomedical Reports 3.1 (2015): 78-82.
Chicago
Wang, W., Zhang, Y., Gao, M., Wang, J., Hou, Y."Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction". Biomedical Reports 3, no. 1 (2015): 78-82. https://doi.org/10.3892/br.2014.366