Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device

  • Authors:
    • Xin Wu
    • Yubo Li
    • Daoqing Xu
    • Hong Zhou
    • Jinlei Wang
    • Xuejun Guo
    • Yanjun Zhang
  • View Affiliations

  • Published online on: November 11, 2014     https://doi.org/10.3892/br.2014.382
  • Pages: 51-54
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Abstract

The aim of the present study was to investigate the characteristics of Su Xiao Jiu Xin dripping pill absorption in the buccal mucosa of healthy volunteers. This pill is a traditional Chinese medicine that is widely used as an emergency treatment for cardiovascular and cerebrovascular diseases. It is sublingually administered and can be absorbed in the buccal mucosa. In the present study, a method was developed to investigate the absorption characteristics in the buccal mucosa of healthy volunteers via a circulating device by gas chromatography‑mass spectrometry and high‑performance liquid chromatography. The five main efficacy components associated with cardiovascular and cerebrovascular diseases, which are borneol, isoborneol, ligustilide, n‑butylphthalide and ferulic acid, were detected and rapidly absorbed. Among these components, four exhibited good absorption, thus confirming that the method developed is efficient for analysis of the absoption characteristics.
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January-February 2015
Volume 3 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Wu X, Li Y, Xu D, Zhou H, Wang J, Guo X and Zhang Y: Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device. Biomed Rep 3: 51-54, 2015.
APA
Wu, X., Li, Y., Xu, D., Zhou, H., Wang, J., Guo, X., & Zhang, Y. (2015). Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device. Biomedical Reports, 3, 51-54. https://doi.org/10.3892/br.2014.382
MLA
Wu, X., Li, Y., Xu, D., Zhou, H., Wang, J., Guo, X., Zhang, Y."Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device". Biomedical Reports 3.1 (2015): 51-54.
Chicago
Wu, X., Li, Y., Xu, D., Zhou, H., Wang, J., Guo, X., Zhang, Y."Gas chromatography‑mass spectrometry and high‑performance liquid chromotagraphy analysis of the drug absorption characteristics in the buccal mucosa via a circulating device". Biomedical Reports 3, no. 1 (2015): 51-54. https://doi.org/10.3892/br.2014.382