Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines
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- Published online on: November 14, 2014 https://doi.org/10.3892/br.2014.385
- Pages: 115-117
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Abstract
Prostate cancer has become a leading cause of mortality in humans. Previous studies have shown the potential anticancer properties of kaempferol‑3‑O‑rhamnoside in breast cancer cell lines. In the present study, the anticancer potential of kaempferol‑3‑O‑rhamnoside was investigated in LNCaP human prostate cancer cell lines. The inhibition of cell proliferation was investigated using MTT assays, whereas its ability to induce the caspase‑cascade pathway was investigated by western blotting. The results showed that kaempferol‑3‑O‑rhamnoside inhibits the proliferation of LNCaP cells in a dose‑dependent manner by upregulating the expression of caspase‑8, caspase‑9, caspase‑3 and poly (ADP‑ribose) polymerase proteins. Although further studies are required, the results of the present study indicate the potential application of kaempferol‑3‑O‑rhamnoside in cancer treatment.
