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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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May-2015 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining

  • Authors:
    • Jiajia Xuan
    • Yunfeng Zhang
    • Xiujun Zhang
    • Fen Hu

  • View Affiliations / Copyright

    Affiliations: College of Life Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China, Department of Life Sciences, Tangshan Normal University, Tangshan, Hebei 063000, P.R. China, College of Psycology, Hebei United University, Tangshan, Hebei 063000, P.R. China
  • Pages: 395-397
    |
    Published online on: January 27, 2015
       https://doi.org/10.3892/br.2015.420
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Abstract

Although matrix metalloproteinase‑1 (MMP‑1) has been considered a factor of crucial importance for breast cancer cells invasion and metastasis, the expression of MMP‑1 in different breast cancer and cancer‑adjacent tissues have not been fully examined. In the present study, immunohistochemical staining was used to detect the MMP‑1 expression in non‑specific invasive ductal carcinoma of the breast, cancer‑adjacent normal breast tissue, lymph node metastatic non‑specific invasive ductal carcinoma of the breast and normal lymph node tissue. The results showed that MMP‑1 expression is different in the above tissues. MMP‑1 had a positive expression in normal lymph node tissue and lymph node metastatic non‑specific invasive ductal carcinoma. The MMP‑1 negative expression rate was only 6.1% in non‑specific invasive ductal carcinoma of the breast and 2.9% in cancer‑adjacent normal breast tissue respectively. MMP‑1 expression is higher in non‑specific invasive ductal carcinoma and lymph node metastatic non‑specific invasive ductal carcinoma compared to cancer‑adjacent normal breast tissue and normal lymph node tissue. In conclusion, higher expression of MMP‑1 in breast cancer may play a crucial role in promoting breast cancer metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Xuan J, Zhang Y, Zhang X and Hu F: Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining. Biomed Rep 3: 395-397, 2015.
APA
Xuan, J., Zhang, Y., Zhang, X., & Hu, F. (2015). Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining. Biomedical Reports, 3, 395-397. https://doi.org/10.3892/br.2015.420
MLA
Xuan, J., Zhang, Y., Zhang, X., Hu, F."Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining". Biomedical Reports 3.3 (2015): 395-397.
Chicago
Xuan, J., Zhang, Y., Zhang, X., Hu, F."Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining". Biomedical Reports 3, no. 3 (2015): 395-397. https://doi.org/10.3892/br.2015.420
Copy and paste a formatted citation
x
Spandidos Publications style
Xuan J, Zhang Y, Zhang X and Hu F: Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining. Biomed Rep 3: 395-397, 2015.
APA
Xuan, J., Zhang, Y., Zhang, X., & Hu, F. (2015). Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining. Biomedical Reports, 3, 395-397. https://doi.org/10.3892/br.2015.420
MLA
Xuan, J., Zhang, Y., Zhang, X., Hu, F."Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining". Biomedical Reports 3.3 (2015): 395-397.
Chicago
Xuan, J., Zhang, Y., Zhang, X., Hu, F."Matrix metalloproteinase‑1 expression in breast cancer and cancer‑adjacent tissues by immunohistochemical staining". Biomedical Reports 3, no. 3 (2015): 395-397. https://doi.org/10.3892/br.2015.420
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