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Article

Expression of MALAT1 in the peripheral whole blood of patients with lung cancer

  • Authors:
    • Fengjie Guo
    • Fang Yu
    • Jing Wang
    • Yongwen Li
    • Ying Li
    • Zhigang Li
    • Qinghua Zhou
  • View Affiliations / Copyright

    Affiliations: Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Laboratories, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China
  • Pages: 309-312
    |
    Published online on: February 2, 2015
       https://doi.org/10.3892/br.2015.422
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Abstract

A blood‑based biomarker assay is a non‑invasive way to screen that can identify lung cancer at an earlier stage to improve the clinical outcome. MALAT1 is a broadly expressed, long non‑coding RNA in human tissues and is overexpressed in numerous human carcinomas. The potential of MALAT1 in the whole blood of lung cancer was evaluated. In the present study, blood samples of patients with lung cancer and healthy volunteers (controls) were recruited and analyzed by quantitative polymerase chain reaction (qPCR) for MALAT1 expression and clinicopathological data. Lung cancer tissues were also analyzed by qPCR. The expression of MALAT1 in the whole blood of lung cancer was lower compared to the control. The area under the receiver operator curve was 0.718 (P<0.001). Relatively, the expression of MALAT1 was stronger in the whole blood of lung cancer with metastasis compared to non‑metastasis. Additionally, the whole blood with bone or brain metastasis exhibited a higher expression of MALAT1 compared to the blood with lymph node or pleura metastasis. Subsequently, a lower expression of MALAT1 was detected in metastatic lymph node tissues than that of the carcinoma in situ of the lung. Taken together, these results indicate that MALAT1 as a biomarker to screen lung cancer may represent a host response to lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Guo F, Yu F, Wang J, Li Y, Li Y, Li Z and Zhou Q: Expression of MALAT1 in the peripheral whole blood of patients with lung cancer. Biomed Rep 3: 309-312, 2015.
APA
Guo, F., Yu, F., Wang, J., Li, Y., Li, Y., Li, Z., & Zhou, Q. (2015). Expression of MALAT1 in the peripheral whole blood of patients with lung cancer. Biomedical Reports, 3, 309-312. https://doi.org/10.3892/br.2015.422
MLA
Guo, F., Yu, F., Wang, J., Li, Y., Li, Y., Li, Z., Zhou, Q."Expression of MALAT1 in the peripheral whole blood of patients with lung cancer". Biomedical Reports 3.3 (2015): 309-312.
Chicago
Guo, F., Yu, F., Wang, J., Li, Y., Li, Y., Li, Z., Zhou, Q."Expression of MALAT1 in the peripheral whole blood of patients with lung cancer". Biomedical Reports 3, no. 3 (2015): 309-312. https://doi.org/10.3892/br.2015.422
Copy and paste a formatted citation
x
Spandidos Publications style
Guo F, Yu F, Wang J, Li Y, Li Y, Li Z and Zhou Q: Expression of MALAT1 in the peripheral whole blood of patients with lung cancer. Biomed Rep 3: 309-312, 2015.
APA
Guo, F., Yu, F., Wang, J., Li, Y., Li, Y., Li, Z., & Zhou, Q. (2015). Expression of MALAT1 in the peripheral whole blood of patients with lung cancer. Biomedical Reports, 3, 309-312. https://doi.org/10.3892/br.2015.422
MLA
Guo, F., Yu, F., Wang, J., Li, Y., Li, Y., Li, Z., Zhou, Q."Expression of MALAT1 in the peripheral whole blood of patients with lung cancer". Biomedical Reports 3.3 (2015): 309-312.
Chicago
Guo, F., Yu, F., Wang, J., Li, Y., Li, Y., Li, Z., Zhou, Q."Expression of MALAT1 in the peripheral whole blood of patients with lung cancer". Biomedical Reports 3, no. 3 (2015): 309-312. https://doi.org/10.3892/br.2015.422
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