Magnesium prevents β‑glycerophosphate‑induced calcification in rat aortic vascular smooth muscle cells

  • Authors:
    • Yaling Bai
    • Junxia Zhang
    • Jinsheng Xu
    • Liwen Cui
    • Huiran Zhang
    • Shenglei Zhang
    • Xunwei Feng
  • View Affiliations

  • Published online on: May 27, 2015     https://doi.org/10.3892/br.2015.473
  • Pages: 593-597
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Abstract

Vascular calcification (VC), in which high serum phosphate plays a critical role, is one major problem in patients with chronic kidney disease. Clinical studies report that magnesium has a protective effect on VC. However, the studies regarding the impact of high serum magnesium on VC at a cellular level are few and require further investigation. Therefore, the present study explored the effect of magnesium on calcification induced by β‑glycerophosphate (BGP) in rat aortic vascular smooth muscle cells (RAVSMCs). In the present study, the addition of magnesium decreased calcium deposition, which was increased by BGP. Higher magnesium levels inhibited BGP‑induced alkaline phosphatase (ALP) activity and decreased the expression of core‑binding factor α‑1 (Cbfα1). In conclusion, higher magnesium levels prevented BGP‑induced calcification in RAVSMCs and inhibited the expression of Cbfα1 and ALP. Thus, magnesium is influencing the expression of Cbfα1 and ALP associated with VC and may have the potential to serve as a role for VC in clinical situations.
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July-2015
Volume 3 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Bai Y, Zhang J, Xu J, Cui L, Zhang H, Zhang S and Feng X: Magnesium prevents β‑glycerophosphate‑induced calcification in rat aortic vascular smooth muscle cells. Biomed Rep 3: 593-597, 2015.
APA
Bai, Y., Zhang, J., Xu, J., Cui, L., Zhang, H., Zhang, S., & Feng, X. (2015). Magnesium prevents β‑glycerophosphate‑induced calcification in rat aortic vascular smooth muscle cells. Biomedical Reports, 3, 593-597. https://doi.org/10.3892/br.2015.473
MLA
Bai, Y., Zhang, J., Xu, J., Cui, L., Zhang, H., Zhang, S., Feng, X."Magnesium prevents β‑glycerophosphate‑induced calcification in rat aortic vascular smooth muscle cells". Biomedical Reports 3.4 (2015): 593-597.
Chicago
Bai, Y., Zhang, J., Xu, J., Cui, L., Zhang, H., Zhang, S., Feng, X."Magnesium prevents β‑glycerophosphate‑induced calcification in rat aortic vascular smooth muscle cells". Biomedical Reports 3, no. 4 (2015): 593-597. https://doi.org/10.3892/br.2015.473