Efficacy of traditional Chinese medicine in treating cancer (Review)
- Authors:
- Jiao Nie
- Changlin Zhao
- Li Deng
- Jia Chen
- Bin Yu
- Xianlin Wu
- Peng Pang
- Xiaoyin Chen
-
Affiliations: Department of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou, Guangdong 510632, P.R. China - Published online on: November 5, 2015 https://doi.org/10.3892/br.2015.537
- Pages: 3-14
This article is mentioned in:
Abstract
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Smith RA, Manassaram-Baptiste D, Brooks D, Doroshenk M, Fedewa S, Saslow D, Brawley OW and Wender R: Cancer screening in the United States, 2015: A review of current American cancer society guidelines and current issues in cancer screening. CA Cancer J Clin. 65:30–54. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Bray F, Jemal A, Grey N, Ferlay J and Forman D: Global cancer transitions according to the Human Development Index (2008–2030): A population-based study. Lancet Oncol. 13:790–801. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Adams C, Grey N, Magrath I, Miller A and Torode J: The World Cancer Declaration: Is the world catching up? Lancet Oncol. 11:1018–1020. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Bailly C: Ready for a comeback of natural products in oncology. Biochem Pharmacol. 77:1447–1457. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Yang G, Li X, Zhang Y, Yang J, Chang J, Sun X, Zhou X, Guo Y, Xu Y, et al: Traditional Chinese medicine in cancer care: A review of controlled clinical studies published in chinese. PLoS One. 8:e603382013. View Article : Google Scholar : PubMed/NCBI | |
|
Sen T and Samanta SK: Medicinal plants, human health and biodiversity: A broad review. Adv Biochem Eng Biotechnol. 147:59–110. 2015.PubMed/NCBI | |
|
Casey SC, Amedei A, Aquilano K, Azmi AS, Benencia F, Bhakta D, Bilsland AE, Boosani CS, Chen S, Ciriolo MR, et al: Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin Cancer Biol. Apr 10–2015.(Epub ahead of print) doi: 10.1016/j.semcancer.2015.02.007. View Article : Google Scholar : PubMed/NCBI | |
|
Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 71:1397–1421. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Qi F, Zhao L, Zhou A, Zhang B, Li A, Wang Z and Han J: The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer. Biosci Trends. 9:16–34. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jenkins VK, Timmons AK and McCall K: Diversity of cell death pathways: Insight from the fly ovary. Trends Cell Biol. 23:567–574. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Boatright KM and Salvesen GS: Mechanisms of caspase activation. Curr Opin Cell Biol. 15:725–731. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Romero A, Novoa B and Figueras A: The complexity of apoptotic cell death in mollusks: An update. Fish Shellfish Immunol. 46:79–87. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hengartner MO: The biochemistry of apoptosis. Nature. 12:770–776. 2000. View Article : Google Scholar | |
|
Hensley P, Mishra M and Kyprianou N: Targeting caspases in cancer therapeutics. Biol Chem. 394:831–843. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
de Poot SA, Lai KW, van der Wal L, Plasman K, Van Damme P, Porter AC, Gevaert K and Bovenschen N: Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis. Cell Death Differ. 21:416–426. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chuang CH, Wang WJ, Li CF, Ko CY, Chou YH, Chuu CP, Cheng TL and Wang JM: The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer. Cell Death Dis. 5:e12202014. View Article : Google Scholar : PubMed/NCBI | |
|
Lin J, Chen Y, Wei L, Chen X, Xu W, Hong Z, Sferra TJ and Peng J: Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. Int J Oncol. 37:1331–1338. 2010.PubMed/NCBI | |
|
Ling Q, Xu X, Wei X, Wang W, Zhou B, Wang B and Zheng S: Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J Exp Clin Cancer Res. 30:662011. View Article : Google Scholar : PubMed/NCBI | |
|
Guo B, Zhang T, Su J, Wang K and Li X: Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells. Cancer Chemother Pharmacol. 75:353–363. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hu M, Zhao M, An C, Yang M, Li Q, Zhang Y, Suetsugu A, Tome Y, Yano S, Fu Y, et al: Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu. Anticancer Res. 32:2509–2514. 2012.PubMed/NCBI | |
|
Hsu SC and Chung JG: Anticancer potential of emodin. BioMedicine. 2:108–116. 2012. View Article : Google Scholar | |
|
Zhang YK, Wang YJ, Gupta P and Chen ZS: Multidrug resistance proteins (MRPs) and cancer therapy. AAPS J. 17:802–812. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wilkens S: Structure and mechanism of ABC transporters. F1000 Prime Rep. 7:142015. View Article : Google Scholar | |
|
Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C and Gottesman MM: Targeting multidrug resistance in cancer. Nat Rev Drug Discov. 5:219–234. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Leslie EM, Deeley RG and Cole SP: Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol. 204:216–237. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Fan L, Sun Y, Miao X, Zhang F, Meng J, Han J, Zhang D, Zhang R, Yue Z, et al: Paris saponin VII from Trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation. J Ethnopharmacol. 154:728–734. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Cort A and Ozben T: Natural product modulators to overcome multidrug resistance in cancer. Nutr Cancer. 67:411–423. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Eichhorn T and Efferth T: P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs. J Ethnopharmacol. 141:557–570. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Ugocsai K, Varga A, Molnár P, Antus S and Molnár J: Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP. Vivo. 19:433–438. 2005. | |
|
Nabekura T, Kamiyama S and Kitagawa S: Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. Biochem Biophys Res Commun. 327:866–870. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Xie XH, Zhao H, Hu YY and Gu XD: Germacrone reverses Adriamycin resistance through cell apoptosis in multidrug-resistant breast cancer cells. Exp Ther Med. 8:1611–1615. 2014.PubMed/NCBI | |
|
Hu T, To KK, Wang L, Zhang L, Lu L, Shen J, Chan RL, Li M, Yeung JH and Cho CH: Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza. Phytomedicine. 21:1264–1272. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Adams M, Mahringer A, Kunert O, Fricker G, Efferth T and Bauer R: Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa. Planta Med. 73:1554–1557. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Adams M, Mahringer A, Bauer R, Fricker G and Efferth T: In vitro cytotoxicity and P-glycoprotein modulating effects of geranylated furocoumarins from Tetradium daniellii. Planta Med. 73:1475–1478. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wu JY, Yu ZL, Fong WF and Shi YQ: Chemotherapeutic activities of Carthami Flos and its reversal effect on multidrug resistance in cancer cells. Afr J Tradit Complement Altern Med. 10:36–40. 2013.PubMed/NCBI | |
|
Gordon MS, Mendelson DS and Kato G: Tumor angiogenesis and novel antiangiogenic strategies. Int J Cancer. 126:1777–1787. 2010.PubMed/NCBI | |
|
Bikfalvi A, Moenner M, Javerzat S, North S and Hagedorn M: Inhibition of angiogenesis and the angiogenesis/invasion shift. Biochem Soc Trans. 39:1560–1564. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ziche M and Morbidelli L: Molecular regulation of tumour angiogenesis by nitric oxide. Eur Cytokine Netw. 20:164–170. 2009.PubMed/NCBI | |
|
Jinushi M: Immune regulation of therapy-resistant niches: Emerging targets for improving anticancer drug responses. Cancer Metastasis Rev. 33:737–745. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, Rathmell WK, Generali D, Nagaraju GP, El-Rayes B, Ribatti D, et al: Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol. Jan 15–2015.(Epub ahead of print) doi: 10.1016/j.semcancer.2015.01.001. View Article : Google Scholar | |
|
Cook KM and Figg WD: Angiogenesis inhibitors: Current strategies and future prospects. CA Cancer J Clin. 60:222–243. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lu KV, Chang JP, Parachoniak CA, Pandika MM, Aghi MK, Meyronet D, Isachenko N, Fouse SD, Phillips JJ, Cheresh DA, et al: VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell. 22:21–35. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Eikesdal HP and Kalluri R: Drug resistance associated with antiangiogenesis therapy. Semin Cancer Biol. 19:310–317. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Wei L, Lin J, Xu W, Cai Q, Shen A, Hong Z and Peng J: Scutellaria barbata D. Don inhibits tumor angiogenesis via suppression of Hedgehog pathway in a mouse model of colorectal cancer. Int J Mol Sci. 13:9419–9430. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yan B, Liu L, Zhao Y, Xiu LJ, Sun DZ, Liu X, Lu Y, Shi J, Zhang YC, Li YJ, et al: Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells. World J Gastroenterol. 20:13105–13118. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wang XF, Zhou QM, Du J, Zhang H, Lu YY and Su SB: Baicalin suppresses migration, invasion and metastasis of breast cancer via p38MAPK signaling pathway. Anticancer Agents Med Chem. 13:923–931. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Shen A, Lin J, Chen Y, Lin W, Liu L, Hong Z, Sferra TJ and Peng J: Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways. Oncol Rep. 30:1701–1706. 2013.PubMed/NCBI | |
|
Li F, Wang Y, Wang X, Li J, Cui H and Niu M: Ganoderic acids suppress growth and angiogenesis by modulating the NF-κB signaling pathway in breast cancer cells. Int J Clin Pharmacol Ther. 50:712–721. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wen-Sheng W: ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. Oncogene. 22:955–963. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Lee Y-C, Cheng TH, Lee JS, Chen JH, Liao YC, Fong Y, Wu CH and Shih YW: Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells. Mol Cell Biochem. 347:103–115. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wang N and Feng Y, Cheung F, Wang X, Zhang Z and Feng Y: A Chinese medicine formula Gegen Qinlian decoction suppresses expansion of human renal carcinoma with inhibition of matrix metalloproteinase-2. Integr Cancer Ther. 14:75–85. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Spurrell EL and Lockley M: Adaptive immunity in cancer immunology and therapeutics. Ecancermedicalscience. 8:4412014.PubMed/NCBI | |
|
Xiao W, Wu K, Yin M, Han S, Ding Y, Qiao A, Lu G, Deng B, Bo P and Gong W: Wogonin inhibits tumor-derived regulatory molecules by suppressing STAT3 signaling to promote tumor immunity. J Immunother. 38:167–84. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Fridman WH, Pagès F, Sautès-Fridman C and Galon J: The immune contexture in human tumours: Impact on clinical outcome. Nat Rev Cancer. 12:298–306. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Huang CF, Lin SS, Liao PH, Young SC and Yang C-C: The immunopharmaceutical effects and mechanisms of herb medicine. Cell Mol Immunol. 5:23–31. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Peng Q, Cai H, Sun X, Li X, Mo Z and Shi J: Alocasia cucullata exhibits strong antitumor effect in vivo by activating antitumor immunity. PLoS One. 8:e753282013. View Article : Google Scholar : PubMed/NCBI | |
|
Ma YH, Cheng WZ, Gong F, Ma AL, Yu QW, Zhang JY, Hu CY, Chen XH and Zhang DQ: Active Chinese mistletoe lectin-55 enhances colon cancer surveillance through regulating innate and adaptive immune responses. World J Gastroenterol. 14:5274–5281. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Sun S, Zheng K, Zhao H, Lu C, Liu B, Yu C, Zhang G, Bian Z, Lu A and He X: Regulatory effect of astragalus polysaccharides on intestinal intraepithelial γδT cells of tumor bearing mice. Molecules. 19:15224–15236. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Su ZY and Sheen LY: An evidence-based perspective of Ganoderma Lucidum (Lucid Ganoderma) for cancer patients. Evidence-based Anticancer Materia Medica. Cho W.C.S.: Springer. 245–263. 2011. View Article : Google Scholar | |
|
de la Taille A, Hayek OR, Burchardt M, Burchardt T and Katz AE: Role of herbal compounds (PC-SPES) in hormone-refractoryprostate cancer: Two case reports. J Altern Complement Med. 6:449–451. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Hsieh TC and Wu JM: Mechanism of action of herbal supplement PC-SPES: Elucidation of effects of individual herbs of PC-SPES on proliferation and prostate specific gene expression in androgen-dependent LNCaP cells. Int J Oncol. 20:583–588. 2002.PubMed/NCBI | |
|
Gao Y, Zhou S, Jiang W, Huang M and Dai X: Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest. 32:201–215. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Donohoe CL, Ryan AM and Reynolds JV: Cancer cachexia: Mechanisms and clinical implications. Gastroenterol Res Pract. 2011:6014342011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Wu C, Zhang Y, Liu F, Wang X, Zhao M and Hoffman RM: Comparison of efficacy and toxicity of traditional Chinese medicine (TCM) herbal mixture LQ and conventional chemotherapy on lung cancer metastasis and survival in mouse models. PLoS One. 9:e1098142014. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L, Wu C, Zhang Y, Liu F, Zhao M, Bouvet M and Hoffman RM: Efficacy comparison of traditional Chinese medicine LQ versus gemcitabine in a mouse model of pancreatic cancer. J Cell Biochem. 114:2131–2137. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Qi F, Li A, Inagaki Y, Gao J, Li J, Kokudo N, Li XK and Tang W: Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. Biosci Trends. 4:297–307. 2010.PubMed/NCBI | |
|
Zhou QM, Wang XF, Liu XJ, Zhang H, Lu YY, Huang S and Su SB: Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effects. Eur J Cancer. 47:2240–2247. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Shakibaei M, Kraehe P, Popper B, Shayan P, Goel A and Buhrmann C: Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. BMC Cancer. 15:2502015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang H, Chan YL, Li TL and Wu CJ: Improving cachectic symptoms and immune strength of tumour-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang. Eur J Cancer. 48:1074–1084. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Li SG, Chen HY, Ou-Yang CS, Wang X-X, Yang Z-J, Tong Y and Cho WC: The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: A systematic review and meta-analysis. PLoS One. 8:e576042013. View Article : Google Scholar : PubMed/NCBI | |
|
Singh SR, Tan M and Rameshwar P: Cancer metabolism: Targeting metabolic pathways in cancer therapy. Cancer Lett. 356(2 Pt A): 147–148. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Nowarski R, Gagliani N, Huber S and Flavell RA: Innate immune cells in inflammation and cancer. Cancer Immunol Res. 1:77–84. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Nobili S, Lippi D, Witort E, Donnini M, Bausi L, Mini E and Capaccioli S: Natural compounds for cancer treatment and prevention. Pharmacol Res. 59:365–378. 2009. View Article : Google Scholar : PubMed/NCBI |
