miR-126: A novel regulator in colon cancer (Review)

  • Authors:
    • Weina Huang
    • Jie Lin
    • Hongxuan Zhang
  • View Affiliations

  • Published online on: December 2, 2015     https://doi.org/10.3892/br.2015.549
  • Pages: 131-134
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Abstract

Colon cancer is one of the most common, lethal diseases worldwide. Tumor metastasis and chemotherapy resistance are the main reasons for its poor prognosis and high fatality rate. Tumor development is thought of as one of the most complex cellular events as it is a multi‑step cascading process involving infinite proliferation, invasion and immigration. Recently, increasing studies have demonstrated that microRNA‑126 (miR‑126) has an important role in colon cancer. The expression of miR‑126 decreased significantly in colon cancer, particularly in highly metastatic cell lines. miR‑126 controls tumor cell growth, metastasis and survival via inactivation of the oncogene signaling pathway, indicating that miR‑126 may serve as a therapeutic target for anticancer therapy. Potentially, miR‑126 was also reported to be an ideal molecular target as a novel biomarker for liver metastasis from colorectal cancer due to its changeable expression level. In the present review, the current knowledge regarding regulatory function of miR-126 is summarized along with its underlying mechanisms in colon cancer.
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February-2016
Volume 4 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Huang W, Lin J and Zhang H: miR-126: A novel regulator in colon cancer (Review). Biomed Rep 4: 131-134, 2016.
APA
Huang, W., Lin, J., & Zhang, H. (2016). miR-126: A novel regulator in colon cancer (Review). Biomedical Reports, 4, 131-134. https://doi.org/10.3892/br.2015.549
MLA
Huang, W., Lin, J., Zhang, H."miR-126: A novel regulator in colon cancer (Review)". Biomedical Reports 4.2 (2016): 131-134.
Chicago
Huang, W., Lin, J., Zhang, H."miR-126: A novel regulator in colon cancer (Review)". Biomedical Reports 4, no. 2 (2016): 131-134. https://doi.org/10.3892/br.2015.549