Epigenetics in systemic lupus erythematosus (Review)

  • Authors:
    • Gong Xiao
    • Xiaoxia Zuo
  • View Affiliations

  • Published online on: December 11, 2015     https://doi.org/10.3892/br.2015.556
  • Pages: 135-139
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Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, with mechanisms that remain to be elucidated. Previous studies have proposed that genes and environments are required for lupus to develop and flare. It has been found that epigenetics have a significant influence on SLE. The present review will concentrate on epigenetics in SLE. There are a number of studies reporting that autoreactive T cells and B cells in patients with SLE have evidence of altered patterns of DNA methylation, modifications of histones and microRNA (miRNA). Long noncoding RNAs (lncRNAs) are another type of noncoding RNAs, which have an important role in epigenetics. lncRNAs may possibly become a new hotspot in SLE.
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February-2016
Volume 4 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Xiao G and Zuo X: Epigenetics in systemic lupus erythematosus (Review). Biomed Rep 4: 135-139, 2016.
APA
Xiao, G., & Zuo, X. (2016). Epigenetics in systemic lupus erythematosus (Review). Biomedical Reports, 4, 135-139. https://doi.org/10.3892/br.2015.556
MLA
Xiao, G., Zuo, X."Epigenetics in systemic lupus erythematosus (Review)". Biomedical Reports 4.2 (2016): 135-139.
Chicago
Xiao, G., Zuo, X."Epigenetics in systemic lupus erythematosus (Review)". Biomedical Reports 4, no. 2 (2016): 135-139. https://doi.org/10.3892/br.2015.556