XB130: A novel adaptor protein in cancer signal transduction (Review)
- Authors:
- Ruiyao Zhang
- Jingyao Zhang
- Qifei Wu
- Fandi Meng
- Chang Liu
-
Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shannxi 710061, P.R. China, Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shannxi 710061, P.R. China - Published online on: February 1, 2016 https://doi.org/10.3892/br.2016.588
- Pages: 300-306
This article is mentioned in:
Abstract
Flynn DC: Adaptor proteins. Oncogene. 20:6270–6272. 2001. View Article : Google Scholar : PubMed/NCBI | |
Pawson T and Scott JD: Signaling through scaffold, anchoring and adaptor proteins. Science. 278:2075–2080. 1997. View Article : Google Scholar : PubMed/NCBI | |
Tsyba L, Nikolaienko O, Dergai O, Dergai M, Novokhatska O, Skrypkina I and Rynditch A: Intersectin multidomain adaptor proteins: Regulation of functional diversity. Gene. 473:67–75. 2011. View Article : Google Scholar : PubMed/NCBI | |
Koch CA, Anderson D, Moran MF, Ellis C and Pawson T: SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins. Science. 252:668–674. 1991. View Article : Google Scholar : PubMed/NCBI | |
Cantley LC: The phosphoinositide 3-kinase pathway. Science. 296:1655–1657. 2002. View Article : Google Scholar : PubMed/NCBI | |
Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF and Huganir RL: GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature. 386:279–284. 1997. View Article : Google Scholar : PubMed/NCBI | |
Denlinger LC, Fisette PL, Sommer JA, Watters JJ, Prabhu U, Dubyak GR, Proctor RA and Bertics PJ: Cutting edge: The nucleotide receptor P2X7 contains multiple protein-and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide. J Immunol. 167:1871–1876. 2001. View Article : Google Scholar : PubMed/NCBI | |
Schlaepfer DD, Hanks SK, Hunter T and van der Geer P: Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 372:786–791. 1994. View Article : Google Scholar : PubMed/NCBI | |
Kurokawa K, Mochizuki N, Ohba Y, Mizuno H, Miyawaki A and Matsuda M: A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo. J Biol Chem. 276:31305–31310. 2001. View Article : Google Scholar : PubMed/NCBI | |
Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T and Pearse BM: Functional organization of clathrin in coats: Combining electron cryomicroscopy and X-ray crystallography. Mol Cell. 3:761–770. 1999. View Article : Google Scholar : PubMed/NCBI | |
Zuiderweg ER: Mapping protein-protein interactions in solution by NMR spectroscopy. Biochemistry. 41:1–7. 2002. View Article : Google Scholar : PubMed/NCBI | |
Rosen MK, Yamazaki T, Gish GD, Kay CM, Pawson T and Kay LE: Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein. Nature. 374:477–479. 1995. View Article : Google Scholar : PubMed/NCBI | |
Dyson HJ and Wright PE: Unfolded proteins and protein folding studied by. Chem Rev. 104:3607–3622. 2004. View Article : Google Scholar : PubMed/NCBI | |
Ren R, Ye ZS and Baltimore D: Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 8:783–795. 1994. View Article : Google Scholar : PubMed/NCBI | |
Feller SM: Crk family adaptors-signalling complex formation and biological roles. Oncogene. 20:6348–6371. 2001. View Article : Google Scholar : PubMed/NCBI | |
Akira S, Takeda K and Kaisho T: Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol. 2:675–680. 2001. View Article : Google Scholar : PubMed/NCBI | |
Liu SK, Fang N, Koretzky GA and McGlade CJ: The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr Biol. 9:67–75. 1999. View Article : Google Scholar : PubMed/NCBI | |
Liu SK and McGlade CJ: Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc. Oncogene. 17:3073–3082. 1998. View Article : Google Scholar : PubMed/NCBI | |
Clements JL, Yang B, Ross-Barta SE, Eliason SL, Hrstka RF, Williamson RA and Koretzky GA: Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science. 281:416–419. 1998. View Article : Google Scholar : PubMed/NCBI | |
Parsons JT: Focal adhesion kinase: The first ten years. J Cell Sci. 116:1409–1416. 2003. View Article : Google Scholar : PubMed/NCBI | |
Bustelo XR: Vav proteins, adaptors and cell signaling. Oncogene. 20:6372–6381. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tybulewicz VL: Vav-family proteins in T-cell signalling. Current Opin Immunol. 17:267–274. 2005. View Article : Google Scholar | |
Defilippi P, Di Stefano P and Cabodi S: P130Cas: A versatile scaffold in signaling networks. Trends Cell Biol. 16:257–263. 2006. View Article : Google Scholar : PubMed/NCBI | |
Luttrell LM, Daaka Y and Lefkowitz RJ: Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol. 11:177–183. 1999. View Article : Google Scholar : PubMed/NCBI | |
Gatesman A, Walker VG, Baisden JM, Weed SA and Flynn DC: Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Mol Cell Biol. 24:7578–7597. 2004. View Article : Google Scholar : PubMed/NCBI | |
Durieu-Trautmann O, Chaverot N, Cazaubon S, Strosberg AD and Couraud P: Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells. J Biol Chem. 269:12536–12540. 1994.PubMed/NCBI | |
Tanaka M, Gupta R and Mayer BJ: Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol Cell Biol. 15:6829–6837. 1995. View Article : Google Scholar : PubMed/NCBI | |
Taganov KD, Boldin MP, Chang KJ and Baltimore D: NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 103:12481–12486. 2006. View Article : Google Scholar : PubMed/NCBI | |
Unterholzner L, Sumner RP, Baran M, Ren H, Mansur DS, Bourke NM, Randow F, Smith GL and Bowie AG: Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. PLoS Pathog. 7:e10022472011. View Article : Google Scholar : PubMed/NCBI | |
Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, et al: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 478:529–533. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, et al: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature. 499:166–171. 2013. View Article : Google Scholar : PubMed/NCBI | |
Flynn DC, Leu TH, Reynolds AB and Parsons JT: Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate. Mol Cell Biol. 13:7892–7900. 1993. View Article : Google Scholar : PubMed/NCBI | |
Qian Y, Baisden JM, Zot HG, Van Winkle WB and Flynn DC: The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. Exp Cell Res. 255:102–113. 2000. View Article : Google Scholar : PubMed/NCBI | |
Baisden JM, Qian Y, Zot HM and Flynn DC: The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. Oncogene. 20:6435–6447. 2001. View Article : Google Scholar : PubMed/NCBI | |
Xu J, Bai XH, Lodyga M, Han B, Xiao H, Keshavjee S, Hu J, Zhang H, Yang BB and Liu M: XB130, a novel adaptor protein for signal transduction. J Biol Chem. 282:16401–16412. 2007. View Article : Google Scholar : PubMed/NCBI | |
Snyder BN, Cho Y, Qian Y, Coad JE, Flynn DC and Cunnick JM: AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes. Eur J Cell Biol. 90:376–389. 2011. View Article : Google Scholar : PubMed/NCBI | |
Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A and Flynn DC: Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. J Cell Biochem. 91:602–620. 2004. View Article : Google Scholar : PubMed/NCBI | |
Saltel F, Daubon T, Juin A, Ganuza IE, Veillat V and Génot E: Invadosomes: Intriguing structures with promise. Eur J Cell Biol. 90:100–107. 2011. View Article : Google Scholar : PubMed/NCBI | |
Proszynski TJ, Gingras J, Valdez G, Krzewski K and Sanes JR: Podosomes are present in a postsynaptic apparatus and participate in its maturation. Proc Natl Acad Sci USA. 106:18373–18378. 2009. View Article : Google Scholar : PubMed/NCBI | |
Shi M, Huang W, Lin L, Zheng D, Zuo Q, Wang L, Wang N, Wu Y, Liao Y and Liao W: Silencing of XB130 is associated with both the prognosis and chemosensitivity of gastric cancer. PloS One. 7:e416602012. View Article : Google Scholar : PubMed/NCBI | |
Lodyga M, Bai X-H, Kapus A and Liu M: Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion. J Cell Sci. 123:4156–4169. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ma AD, Brass LF and Abrams CS: Pleckstrin associates with plasma membranes and induces the formation of membrane projections: Requirements for phosphorylation and the NH2-terminal PH domain. J Cell Biol. 136:1071–1079. 1997. View Article : Google Scholar : PubMed/NCBI | |
Wang T, Pentyala S, Rebecchi MJ and Scarlata S: Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2 and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins. Biochemistry. 38:1517–1524. 1999. View Article : Google Scholar : PubMed/NCBI | |
Gillingham AK and Munro S: Long coiled-coil proteins and membrane traffic. Biochim Biophys Acta. 1641:71–85. 2003. View Article : Google Scholar : PubMed/NCBI | |
Zhang T, Kruys V, Huez G and Gueydan C: AU-rich element-mediated translational control: Complexity and multiple activities of trans-activating factors. Biochem Soc Trans. 30:952–958. 2002. View Article : Google Scholar : PubMed/NCBI | |
Shiozaki A and Liu M: Roles of XB130, a novel adaptor protein, in cancer. J Clin Bioinforma. 1:102011. View Article : Google Scholar : PubMed/NCBI | |
Lodyga M, Xhi C, Anraku M, et al: P-080 Prognostic expression of a novel adaptor protein XB130 innon-small cell lung cancer. Lung Cancer. 49:S1352005. View Article : Google Scholar | |
Shiozaki A, Lodyga M, Bai XH, Nadesalingam J, Oyaizu T, Winer D, Asa SL, Keshavjee S and Liu M: XB130, a novel adaptor protein, promotes thyroid tumor growth. Am J Pathol. 178:391–401. 2011. View Article : Google Scholar : PubMed/NCBI | |
Lodyga M, De Falco V, Bai X, Kapus A, Melillo RM, Santoro M and Liu M: XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway. Oncogene. 28:937–949. 2009. View Article : Google Scholar : PubMed/NCBI | |
Takeshita H, Shiozaki A, Bai XH, Iitaka D, Kim H, Yang BB, Keshavjee S and Liu M: XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells. PloS One. 8:e590572013. View Article : Google Scholar : PubMed/NCBI | |
Yu Z, Jian Z, Shen SH, Purisima E and Wang E: Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. Nucleic Acids Res. 35:152–164. 2007. View Article : Google Scholar : PubMed/NCBI | |
Shi M, Zheng D, Sun L, Wang L, Lin L, Wu Y, Zhou M and Liao W, Liao Y, Zuo Q and Liao W: XB130 promotes proliferation and invasion of gastric cancer cells. J Transl Med. 12:12014. View Article : Google Scholar : PubMed/NCBI | |
Zuo Q, Huang H, Shi M, Zhang F, Sun J, Bin J, Liao Y and Liao W: Multivariate analysis of several molecular markers and clinicopathological features in postoperative prognosis of hepatocellular carcinoma. Anat Rec (Hoboken). 295:423–431. 2012. View Article : Google Scholar : PubMed/NCBI | |
Shiozaki A, Kosuga T, Ichikawa D, Komatsu S, Fujiwara H, Okamoto K, Iitaka D, Nakashima S, Shimizu H, Ishimoto T, et al: XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma. Ann Surg Oncol. 20:3140–3150. 2013. View Article : Google Scholar : PubMed/NCBI | |
Zhang J, Jiang X and Zhang J: Prognostic significance of XB130 expression in surgically resected pancreatic ductal adenocarcinoma. World J Surg Oncol. 12:492014. View Article : Google Scholar : PubMed/NCBI | |
Courtneidge S: Role of Src in signal transduction pathways. The Jubilee Lecture. Biochem Soc Trans. 30:11–17. 2002. View Article : Google Scholar : PubMed/NCBI | |
Xing L, Ge C, Zeltser R, Maskevitch G, Mayer BJ and Alexandropoulos K: c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase. Mol Cell Biol. 20:7363–7377. 2000. View Article : Google Scholar : PubMed/NCBI | |
Martin GS: The hunting of the Src. Nat Rev Mol Cell Biol. 2:467–475. 2001. View Article : Google Scholar : PubMed/NCBI | |
Okutani D, Lodyga M, Han B and Liu M: Src protein tyrosine kinase family and acute inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 291:L129–L141. 2006. View Article : Google Scholar : PubMed/NCBI | |
Tsygankov AY: Non-receptor protein tyrosine kinases. Front Biosci. 8:s595–s635. 2003. View Article : Google Scholar : PubMed/NCBI | |
Williams JC, Weijland A, Gonfloni S, Thompson A, Courtneidge SA, Superti-Furga G and Wierenga RK: The 2.35 A crystal structure of the inactivated form of chicken Src: A dynamic molecule with multiple regulatory interactions. J Mol Biol. 274:757–775. 1997. View Article : Google Scholar : PubMed/NCBI | |
Okada M, Nada S, Yamanashi Y, Yamamoto T and Nakagawa H: CSK: A protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem. 266:24249–24252. 1991.PubMed/NCBI | |
Gregorieff A, Cloutier JF and Veillette A: Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50 csk. J Biol Chem. 273:13217–13222. 1998. View Article : Google Scholar : PubMed/NCBI | |
Bouton AH, Riggins RB and Bruce-Staskal PJ: Functions of the adapter protein Cas: Signal convergence and the determination of cellular responses. Oncogene. 20:6448–6458. 2001. View Article : Google Scholar : PubMed/NCBI | |
Alexandropoulos K and Baltimore D: Coordinate activation of c-Src by SH3-and SH2-binding sites on a novel p130Cas-related protein, Sin. Genes Dev. 10:1341–1355. 1996. View Article : Google Scholar : PubMed/NCBI | |
Nakamoto T, Sakai R, Ozawa K, Yazaki Y and Hirai H: Direct binding of C-terminal region of p130 to SH2 and SH3 domains of Src kinase. J Biol Chem. 271:8959–8965. 1996. View Article : Google Scholar : PubMed/NCBI | |
Shiozaki A, Shen-Tu G, Bai X, Iitaka D, De Falco V, Santoro M, Keshavjee S and Liu M: XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt. PloS One. 7:e436462012. View Article : Google Scholar : PubMed/NCBI | |
Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, et al: Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med. 8:1136–1144. 2002. View Article : Google Scholar : PubMed/NCBI | |
Zhou BP, Liao Y, Xia W, Spohn B, Lee MH and Hung MC: Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol. 3:245–252. 2001. View Article : Google Scholar : PubMed/NCBI | |
Luo J, Manning BD and Cantley LC: Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell. 4:257–262. 2003. View Article : Google Scholar : PubMed/NCBI | |
Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer. 2:489–501. 2002. View Article : Google Scholar : PubMed/NCBI | |
Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F and Takahashi S: Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells. Mol Endocrinol. 26:1043–1055. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhao J, Bai X, Wang Y, Keshavjee S and Liu M: Potential role of XB130 in the regulation of airway epithelium repair and regeneration after transplantation. The Journal of Heart and Lung Transplantation. 32:S2962013. View Article : Google Scholar |