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Review

99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review)

  • Authors:
    • Qian Wu
    • Yang Ni
    • Qingrui Yang
    • Hongsheng Sun
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 400-402
    |
    Published online on: February 23, 2016
       https://doi.org/10.3892/br.2016.609
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Abstract

Technetium 99 conjugated with methylene diphosphonate, which is an anti‑inflammatory drug, can inhibit macrophage infiltration and downregulate a number of proinflammatory cytokines, such as tumor necrosis factor‑α and interleukin‑1β. Recently, numerous studies have indicated that it could improve rheumatoid arthritis (RA) activity by upregulating the frequency of peripheral γδ T cells and cluster of differentiation CD4+CD25+Foxp3+ Tregs, affecting the serum cytokine environment, inhibiting osteoclast formation and reducing the concentrations of rheumatoid factor‑immunoglobulin M (IgM)/IgG/IgA. As well, it may have a therapeutic role for choroidal neovascularisation (CNV) and Graves' ophthalmopathy (GO). Therefore, it will be a valuable choice in the treatment of RA, CNV and GO.
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1 

Lai K, Xu L, Jin C, Wu K, Tian Z, Huang C, Zhong X and Ye H: Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro. Invest Ophthalmol Vis Sci. 52:5702–5712. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Choi JK, Kim SW, Kim DS, Lee JY, Lee S, Oh HM, Ha YS, Yoo J, Park PH, Shin TY, et al: Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes. Toxicol Appl Pharmacol. 290:1–9. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Favalli EG, Becciolini A and Biggioggero M: Structural integrity versus radiographic progression in rheumatoid arthritis. RMD Open. 1(Suppl 1): e0000642015. View Article : Google Scholar : PubMed/NCBI

4 

Meednu N, Zhang H, Owen T, Sun W, Wang V, Cistrone C, Rangel-Moreno J, Xing L, Med B and Anolik JH: A link between B cells and bone erosion in rheumatoid arthritis: Receptor activator of nuclear factor kappa-B ligand production by memory B cells. Arthritis Rheumatol. Nov 10–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

5 

Owens GM: Optimizing Rheumatoid Arthritis Therapy: Using Objective Measures of Disease Activity to Guide Treatment. Am Health Drug Benefits. 8:354–360. 2015.PubMed/NCBI

6 

Magyari L, Varszegi D, Kovesdi E, Sarlos P, Farago B, Javorhazy A, Sumegi K, Banfai Z and Melegh B: Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications. World J Orthop. 5:516–536. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Rosado-de-Castro PH, de Lopes Souza SA, Alexandre D, da Barbosa Fonseca LM and Gutfilen B: Rheumatoid arthritis: Nuclear Medicine state-of-the-art imaging. World J Orthop. 5:312–318. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Al-Nahain A, Jahan R and Rahmatullah M: Zingiber officinale: A Potential Plant against Rheumatoid Arthritis. Arthritis. 2014:1590892014. View Article : Google Scholar : PubMed/NCBI

9 

Scarno A, Perrotta FM, Cardini F, Carboni A, Annibali G, Lubrano E and Spadaro A: Beyond the joint: Subclinical atherosclerosis in rheumatoid arthritis. World J Orthop. 5:328–335. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Sonomoto K, Yamaoka K and Tanaka Y: An approach to bone and cartilage repair of rheumatoid arthritis by mesenchymal stem cells. J UOEH. 36:141–146. 2014.(In Japanese). View Article : Google Scholar : PubMed/NCBI

11 

Su D, Shen M, Gu B, Wang X, Wang D, Li X and Sun L: 99 Tc-methylene diphosphonate improves rheumatoid arthritis disease activity by increasing the frequency of peripheral γδ T cells and CD4+ CD25+ Foxp3+ Tregs. Int J Rheum Dis. Jan 28–2014.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

12 

Ji Y, Huo X and Zhang H: Technetium 99Tc methylenediphosphonate inhibits osteoclast formation from PBMCs in patients with rheumatoid arthritis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 34:684–688. 2009.(In Chinese). PubMed/NCBI

13 

Gong W, Dou H, Liu X, Sun L and Hou Y: Technetium-99 conjugated with methylene diphosphonate inhibits receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis. Clin Exp Pharmacol Physiol. 39:886–893. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Huang A, Yu L and Shen L: Effect of technetium-99 conjugated with methylene diphosphonate on IgM-RF, IgG-RF and IgA-RF. J Huazhong Univ Sci Technolog Med Sci. 23:266–268. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Wu YG, Ma QL and Liu GF: Effect of 99Tc-MDP on cytokine production by peripheral blood mononuclear cells of patients with rheumatoid arthritis. Hunan Yi Ke Da Xue Xue Bao. 27:173–175. 2002.(In Chinese). PubMed/NCBI

16 

Wong TY, Ohno-Matsui K, Leveziel N, Holz FG, Lai TY, Yu HG, Lanzetta P, Chen Y and Tufail A: Myopic choroidal neovascularisation: Current concepts and update on clinical management. Br J Ophthalmol. 99:289–296. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Li T, Aredo B, Zhang K, Zhong X, Pulido JS, Wang S, He YG, Huang X, Brekken RA and Ufret-Vincenty RL: Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo. Invest Ophthalmol Vis Sci. 56:7137–7145. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Weber ML and Heier JS: Choroidal Neovascularization Secondary to Myopia, Infection and Inflammation. Dev Ophthalmol. 55:167–175. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Nagai N, Ju M, Izumi-Nagai K, Robbie SJ, Bainbridge JW, Gale DC, Pierre E, Krauss AH, Adamson P, Shima DT, et al: Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability. Am J Pathol. 185:2534–2549. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Baxter SL, Pistilli M, Pujari SS, Liesegang TL, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, et al: Risk of choroidal neovascularization among the uveitides. Am J Ophthalmol. 156:468–477.e2. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Bahn RS: Clinical review 157: Pathophysiology of Graves' ophthalmopathy: the cycle of disease. J Clin Endocrinol Metab. 88:1939–1946. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Wei H, Guan M, Qin Y, Xie C, Fu X, Gao F and Xue Y: Circulating levels of miR-146a and IL-17 are significantly correlated with the clinical activity of Graves' ophthalmopathy. Endocr J. 61:1087–1092. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Hahn E, Laperriere N, Millar BA, Oestreicher J, McGowan H, Krema H, Gill H, DeAngelis D, Hurwitz J, Tucker N, et al: Orbital radiation therapy for Graves' ophthalmopathy: Measuring clinical efficacy and impact. Pract Radiat Oncol. 4:233–239. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Bartley GB, Fatourechi V, Kadrmas EF, Jacobsen SJ, Ilstrup DM, Garrity JA and Gorman CA: The incidence of Graves' ophthalmopathy in Olmsted County, Minnesota. Am J Ophthalmol. 120:511–517. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Burch HB and Wartofsky L: Graves' ophthalmopathy: Current concepts regarding pathogenesis and management. Endocr Rev. 14:747–793. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Perros P, Crombie AL and Kendall-Taylor P: Natural history of thyroid associated ophthalmopathy. Clin Endocrinol (Oxf). 42:45–50. 1995. View Article : Google Scholar : PubMed/NCBI

27 

Zang S, Ponto KA and Kahaly GJ: Clinical review: Intravenous glucocorticoids for Graves' orbitopathy: efficacy and morbidity. J Clin Endocrinol Metab. 96:320–332. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Prummel MF and Wiersinga WM: Immunomodulatory treatment of Graves' ophthalmopathy. Thyroid. 8:545–548. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Mou P, Jiang LH, Zhang Y, Li YZ, Lou H, Zeng CC, Wang QH, Cheng JW and Wei RL: Common Immunosuppressive Monotherapy for Graves' Ophthalmopathy: A Meta-Analysis. PLoS One. 10:e01395442015. View Article : Google Scholar : PubMed/NCBI

30 

Yan SX, Wang Y, Peng GJ, Lu XP and Fu Y: Effects of technetium-99 methylenediphosphonate on cytokine-induced activation of retro-ocular fibroblasts from patients with Graves' ophthalmopathy. Nucl Med Commun. 32:142–146. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Pan W, Tan T, Wang Q and Zheng J: Treatment of patients with Graves' ophthalmopathy by immunosuppressive agent and 99Tc-MDP. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 19:300–301, 323. 2002.(In Chinese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu Q, Ni Y, Yang Q and Sun H: 99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review). Biomed Rep 4: 400-402, 2016.
APA
Wu, Q., Ni, Y., Yang, Q., & Sun, H. (2016). 99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review). Biomedical Reports, 4, 400-402. https://doi.org/10.3892/br.2016.609
MLA
Wu, Q., Ni, Y., Yang, Q., Sun, H."99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review)". Biomedical Reports 4.4 (2016): 400-402.
Chicago
Wu, Q., Ni, Y., Yang, Q., Sun, H."99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review)". Biomedical Reports 4, no. 4 (2016): 400-402. https://doi.org/10.3892/br.2016.609
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Q, Ni Y, Yang Q and Sun H: 99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review). Biomed Rep 4: 400-402, 2016.
APA
Wu, Q., Ni, Y., Yang, Q., & Sun, H. (2016). 99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review). Biomedical Reports, 4, 400-402. https://doi.org/10.3892/br.2016.609
MLA
Wu, Q., Ni, Y., Yang, Q., Sun, H."99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review)". Biomedical Reports 4.4 (2016): 400-402.
Chicago
Wu, Q., Ni, Y., Yang, Q., Sun, H."99Tc‑MDP treatment for the therapy of rheumatoid arthritis, choroidal neovascularisation and Graves' ophthalmopathy (Review)". Biomedical Reports 4, no. 4 (2016): 400-402. https://doi.org/10.3892/br.2016.609
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