Adjunctive therapy of Mycobacterium vaccae vaccine in the treatment of multidrug-resistant tuberculosis: A systematic review and meta-analysis

  • Authors:
    • Hong Weng
    • Jing‑Yu Huang
    • Xiang‑Yu Meng
    • Sheng Li
    • Gu‑Qin Zhang
  • View Affiliations

  • Published online on: March 4, 2016     https://doi.org/10.3892/br.2016.624
  • Pages: 595-600
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Abstract

A number of studies have suggested that the Mycobacterium vaccae (MV) vaccine as an adjunctive therapy has a positive effect in the treatment of multidrug‑resistant tuberculosis (MDR‑TB). However, the result is inconclusive. The aim of the present study was to systematically evaluate the effect and safety of MV as an adjunctive therapy in the treatment of MDR‑TB. A computerized search of PubMed, Embase, Cochrane Central Register of Controlled Trials, CBM, CNKI and VIP until October 2014 was conducted to collect the relevant studies. The main outcome measures were the sputum smear positive-turned-negative rate, the absorption rate of TB foci and the closure situation of the TB cavity. Two investigators identified the eligible studies and extracted data independently. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and pooled using the fixed effects model. A total of 25 studies involving 2,281 patients with MDR-TB were included. The pooled OR was 3.84 (95% CI, 3.84‑4.73) for the sputum smear positive-turned-negative, 4.08 (95% CI, 3.08-5.45) for the absorption rate of TB foci, and 3.42 (95% CI, 2.68-4.37) for the closure situation of TB cavity. Therefore, MV has a significant effect as an adjunctive therapy in the treatment of MDR‑TB. However, larger scale multicenter randomized controlled trials are required to confirm this evidence for limited latent bias at present.
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May-2016
Volume 4 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Weng H, Huang JY, Meng XY, Li S and Zhang GQ: Adjunctive therapy of Mycobacterium vaccae vaccine in the treatment of multidrug-resistant tuberculosis: A systematic review and meta-analysis. Biomed Rep 4: 595-600, 2016
APA
Weng, H., Huang, J., Meng, X., Li, S., & Zhang, G. (2016). Adjunctive therapy of Mycobacterium vaccae vaccine in the treatment of multidrug-resistant tuberculosis: A systematic review and meta-analysis. Biomedical Reports, 4, 595-600. https://doi.org/10.3892/br.2016.624
MLA
Weng, H., Huang, J., Meng, X., Li, S., Zhang, G."Adjunctive therapy of Mycobacterium vaccae vaccine in the treatment of multidrug-resistant tuberculosis: A systematic review and meta-analysis". Biomedical Reports 4.5 (2016): 595-600.
Chicago
Weng, H., Huang, J., Meng, X., Li, S., Zhang, G."Adjunctive therapy of Mycobacterium vaccae vaccine in the treatment of multidrug-resistant tuberculosis: A systematic review and meta-analysis". Biomedical Reports 4, no. 5 (2016): 595-600. https://doi.org/10.3892/br.2016.624