Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels in preschool children with nephrotic syndrome

  • Authors:
    • Jianjiang Zhang
    • Huiqin Zeng
    • Shuqin Fu
    • Peipei Shi
    • Miao Wang
    • Li Guo
  • View Affiliations

  • Published online on: March 16, 2016     https://doi.org/10.3892/br.2016.631
  • Pages: 605-608
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Abstract

The aim of the present study was to investigate the changes in the serum Dickkopf-1 (DKK-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) levels in preschoolers with nephrotic syndrome (NS). A total of 50 preschoolers (3-5 years old) with NS and 20 healthy preschoolers (control group) were enrolled in the prospective single-center study. The patients with NS received glucocorticoid treatment and the control group received no treatment. The levels of serum calcium, phosphorus, TRACP-5b, DKK-1 and 25-hydroxyvitamin D3 were measured at baseline and at 3 and 6 months in all the subjects. The levels of DKK‑1 and TRACP‑5b were significantly higher in the NS group prior to treatment when compared to the control group (P<0.05), but did not differ significantly between the two groups following treatment (P>0.05). Therefore, DKK-1 and TRACP-5b can be used as biomarkers of bone formation and bone resorption, respectively, in the early evaluation of bone metabolism.
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May-2016
Volume 4 Issue 5

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Spandidos Publications style
Zhang J, Zeng H, Fu S, Shi P, Wang M and Guo L: Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels in preschool children with nephrotic syndrome . Biomed Rep 4: 605-608, 2016
APA
Zhang, J., Zeng, H., Fu, S., Shi, P., Wang, M., & Guo, L. (2016). Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels in preschool children with nephrotic syndrome . Biomedical Reports, 4, 605-608. https://doi.org/10.3892/br.2016.631
MLA
Zhang, J., Zeng, H., Fu, S., Shi, P., Wang, M., Guo, L."Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels in preschool children with nephrotic syndrome ". Biomedical Reports 4.5 (2016): 605-608.
Chicago
Zhang, J., Zeng, H., Fu, S., Shi, P., Wang, M., Guo, L."Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels in preschool children with nephrotic syndrome ". Biomedical Reports 4, no. 5 (2016): 605-608. https://doi.org/10.3892/br.2016.631