Helicobacter pylori hopQ alleles (type I and II) in gastric cancer

Leylabadlo,Hamed Ebrahimzadeh; Yekani,Mina; Ghotaslou,Reza

doi:10.3892/br.2016.634

Helicobacter pylori hopQ alleles (type I and II) in gastric cancer

Authors:
- Hamed Ebrahimzadeh Leylabadlo
- Mina Yekani
- Reza Ghotaslou
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Affiliations: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 51636-39888, Iran, Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran
Published online on: March 18, 2016 https://doi.org/10.3892/br.2016.634
Pages: 601-604

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Abstract

The Helicobacter pylori (H. pylori) outer membrane protein (HopQ) of is one of the proteins involved in bacterial adherence to gastric mucosa and has been suggested to have a role in the virulence of H. pylori. The aim of the present study was to determine the association between H. pylori virulence types I and II hopQ genotypes and patients with different gastrointestinal diseases. A polymerase chain reaction‑based assay was used to determine the presence of type I and type II hopQ genes in 88 H. pylori strains isolated from H. pylori‑infected patients. Of the total 88 H. pylori isolates, type I and type II hopQ alleles were detected in 52 (59.1%) and 36 (40.9%), respectively. A significant association was found between type I hopQ gene and gastric cancer [odds ratio, 2.3; 95% confidence interval (CI), 1.3‑4.1] and gastric ulcers (odds ratio, 2.5; 95% CI, 1.4‑4.3). A significant association was also identified between the type II hopQ gene and gastric cancer (odds ratio, 2.4; 95% CI, 1.1‑3.0). The association between hopQ type I and hopQ type II genotypes and clinical status suggest that these genes may be helpful in the universal prediction of specific disease risks.

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