Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression (Review)

  • Authors:
    • Jing Lu
    • Feng‑Hou Gao
  • View Affiliations

  • Published online on: March 29, 2016     https://doi.org/10.3892/br.2016.642
  • Pages: 657-663
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Abstract

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a member of the hnRNP family, which exists in the nucleus and the cytoplasm simultaneously. It is a multifunctional protein that can participate in a variety of regulatory progressions of gene expression and signal transduction, such as chromatin remodeling, transcription, RNA alternative splicing and translation. hnRNP K not only directly binds to the kinases, but also recruits the associated factors regarding transcription, splicing and translation to control gene expression, and therefore, it serves as a docking platform for integrating transduction pathways to nucleic acid‑directed processes. Numerous studies also show that abnormal expression of hnRNP K is closely associated with the tumor formation. This protein is overexpressed in numerous types of cancer and its aberrant cytoplasmic localization is also associated with a worse prognosis for patients. These results consistently indicate that hnRNP K has a key role in cancer progression. To understand the hnRNP K pathophysiological process in tumor disease, the previous research results regarding the association between hnRNP K and tumors were reviewed.
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June-2016
Volume 4 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Lu J and Gao FH: Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression (Review). Biomed Rep 4: 657-663, 2016.
APA
Lu, J., & Gao, F. (2016). Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression (Review). Biomedical Reports, 4, 657-663. https://doi.org/10.3892/br.2016.642
MLA
Lu, J., Gao, F."Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression (Review)". Biomedical Reports 4.6 (2016): 657-663.
Chicago
Lu, J., Gao, F."Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression (Review)". Biomedical Reports 4, no. 6 (2016): 657-663. https://doi.org/10.3892/br.2016.642