A meta‑analysis of the association between Behçet's disease and MICA‑A6

Wei,Feiran; Zhang,Yu; Li,Wei

doi:10.3892/br.2016.644

A meta‑analysis of the association between Behçet's disease and MICA‑A6

Authors:
- Feiran Wei
- Yu Zhang
- Wei Li
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Affiliations: Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 100044, P.R. China, Department of Infectious Disease Prevention and School Health, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, P.R. China
Published online on: March 31, 2016 https://doi.org/10.3892/br.2016.644
Pages: 741-745

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Abstract

Behçet's disease (BD) is a multi‑system inflammatory condition with unknown cause, characterized by a triple‑symptom complex of recurrent oral aphthous ulcers, genital ulcers, and uveitis and skin lesions. It predominantly affects people living around the Mediterranean basin and in Japan. The effects of the major histocompatibility complex class I chain related gene A (MICA) A6 allele on susceptibility to Behçet's disease (BD) have been reported previously, however, their results have been unreliable. The present study aimed to determine whether an association between the MICA‑A6 allele and BD susceptibility exists. A total of 12 case‑control studies, examining the association between MICA-A6 and BD and involving 752 cases and 1,175 controls were included in the present meta‑analysis. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The results of meta‑analysis revealed that the frequency of the MICA‑A6 allele in the case group was significantly higher than those in the control groups (P<0.001, OR=2.43, 95% CI: 1.99‑2.97). Sub-group analysis by ethnicity indicated that the association between of MICA‑A6 gene to BD remained in Asian populations (5 cases and 731 controls) and Caucasian populations (242 cases and 444 controls) with OR=2.65, 95% CI: 2.07‑3.38 and OR=2.23, 95% CI: 1.37‑3.62, respectively. These findings demonstrate that MICA‑A6 gene is associated with susceptibility to BD. The MICA‑A6 gene may serve as an early diagnostic marker for BD in the future.

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1	McGonagle D and McDermott MF: A proposed classification of the immunological diseases. PLoS Med. 3:e2972006. View Article : Google Scholar : PubMed/NCBI
2	Günaydin I, Ustündağ C, Kaner G, Pazarli H, Yurdakul S, Hamuryudan V, Yazici Y and Yazici H: The prevalence of Sjögren's syndrome in Behçet's syndrome. J Rheumatol. 21:1662–1664. 1994.PubMed/NCBI
3	Salvarani C, Boiardi L, Mantovani V, Olivieri I, Ciancio G, Cantini F, Salvi F, Malatesta R, Molinotti C, Govoni M, et al: Association of MICA alleles and HLA-B51 in Italian patients with Behçet's disease. J Rheumatol. 28:1867–1870. 2001.PubMed/NCBI
4	de Menthon M, Lavalley MP, Maldini C, Guillevin L and Mahr A: HLA-B51/B5 and the risk of Behçet's disease: A systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum. 61:1287–1296. 2009. View Article : Google Scholar : PubMed/NCBI
5	Bahram S, Bresnahan M, Geraghty DE and Spies T: A second lineage of mammalian major histocompatibility complex class I genes. Proc Natl Acad Sci USA. 91:6259–6263. 1994. View Article : Google Scholar : PubMed/NCBI
6	Zwirner NW, Fernández-Viña MA and Stastny P: MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells and monocytes. Immunogenetics. 47:139–148. 1998. View Article : Google Scholar : PubMed/NCBI
7	Mizuki N, Ota M, Kimura M, Ohno S, Ando H, Katsuyama Y, Yamazaki M, Watanabe K, Goto K, Nakamura S, et al: Triplet repeat polymorphism in the transmembrane region of the MICA gene: A strong association of six GCT repetitions with Behçet disease. Proc Natl Acad Sci USA. 94:1298–1303. 1997. View Article : Google Scholar : PubMed/NCBI
8	Park SH, Park KS, Seo YI, Min DJ, Kim WU, Kim TG, Cho CS, Mok JW, Park KS and Kim HY: Association of MICA polymorphism with HLA-B51 and disease severity in Korean patients with Behcet's disease. J Korean Med Sci. 17:366–370. 2002. View Article : Google Scholar : PubMed/NCBI
9	Nishiyama M, Takahashi M, Manaka K, Suzuki S, Saito M and Nakae K: Microsatellite polymorphisms of the MICA gene among Japanese patients with Behçet's disease. Can J Ophthalmol. 41:210–215. 2006. View Article : Google Scholar : PubMed/NCBI
10	Jackson D, White IR and Riley RD: Quantifying the impact of between-study heterogeneity in multivariate meta-analyses. Stat Med. 31:3805–3820. 2012. View Article : Google Scholar : PubMed/NCBI
11	Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI
12	González-Escribano MF, Rodríguez MR, Aguilar F, Alvarez A, Sanchez-Roman J and Núñez-Roldán A: Lack of association of MICA transmembrane region polymorphism and Behçet's disease in Spain. Tissue Antigens. 54:278–281. 1999. View Article : Google Scholar : PubMed/NCBI
13	Ota M, Mizuki N, Katsuyama Y, Tamiya G, Shiina T, Oka A, Ando H, Kimura M, Goto K, Ohno S and Inoko H: The critical region for Behçet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping. Am J Hum Genet. 64:1406–1410. 1999. View Article : Google Scholar : PubMed/NCBI
14	Yabuki K, Mizuki N, Ota M, Katsuyama Y, Palimeris G, Stavropoulos C, Koumantaki Y, Spyropoulou M, Giziaki E, Kaklamani V, et al: Association of MICA gene and HLA-B*5101 with Behçet's disease in Greece. Invest Ophthalmol Vis Sci. 40:1921–1926. 1999.PubMed/NCBI
15	Mizuki N, Ota M, Yabuki K, Katsuyama Y, Ando H, Palimeris GD, Kaklamani E, Accorinti M, Pivetti-Pezzi P, Ohno S and Inoko H: Localization of the pathogenic gene of Behçet's disease by microsatellite analysis of three different populations. Invest Ophthalmol Vis Sci. 41:3702–3708. 2000.PubMed/NCBI
16	Mizuki N, Yabuki K, Ota M, Verity D, Katsuyama Y, Ando H, Onari K, Goto K, Imagawa Y, Mandanat W, et al: Microsatellite mapping of a susceptible locus within the HLA region for Behçet's disease using Jordanian patients. Hum Immunol. 62:186–190. 2001. View Article : Google Scholar : PubMed/NCBI
17	Mizuki N, Yabuki K, Ota M, Katsuyama Y, Ando H, Nomura E, Funakoshi K, Davatchi F, Chams H, Nikbin B, et al: Analysis of microsatellite polymorphism around the HLA-B locus in Iranian patients with Behçet's disease. Tissue Antigens. 60:396–399. 2002. View Article : Google Scholar : PubMed/NCBI
18	Mizuki N, Ohno S, Ando H, Chen L, Palimeris GD, et al: A strong association between HLA-B*5101 and Behçet's disease in Greek patients. Tissue Antigens. 50:57–60. 1997. View Article : Google Scholar : PubMed/NCBI
19	Yamashita N, Kaneoka H, Kaneko S, Takeno M, Oneda K, Koizumi H, Kogure M, Inaba G and Sakane T: Role of gammadelta T lymphocytes in the development of Behçet's disease. Clin Exp Immunol. 107:241–247. 1997. View Article : Google Scholar : PubMed/NCBI